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IL4 — VEGFA

Text-mined interactions from Literome

Gloddek et al., J Endocrinol 1999 : Pituitary adenylate cyclase activating polypeptide, interleukin-6 and glucocorticoids regulate the release of vascular endothelial growth factor in pituitary folliculostellate cells
Matsumoto et al., Am J Nephrol 1999 (Glomerulonephritis, IGA...) : To gain insight into the immunoregulatory properties of these cytokines, we analyzed the effects of recombinant human IL-4 and IL-10 on VPF release in MCNS patients ... These data demonstrate that IL-4 acts in concert with IL-10 to inhibit VPF release and suggest that they are effective biologic regulators of the VPF responses in vitro
Tsuji et al., Biol Pharm Bull 2000 : Effects of sulfhydryl compounds on interleukin-1 induced vascular endothelial growth factor production in human synovial stromal cells
Griga et al., Hepatogastroenterology 2000 (Inflammatory Bowel Diseases) : Interleukin-4 inhibits the increased production of vascular endothelial growth factor by peripheral blood mononuclear cells in patients with inflammatory bowel disease ... The present study examines the effect of interleukin-4 on the increased VEGF production of PBMCs in patients with IBD ... IL-4 led to a significant reduction of the VEGF production by PBMCs of both active Crohn 's disease patients ( 471.7 +/- 377.5 pg/mL vs. 208.2 +/- 123.2 pg/mL, P = 0.018, n = 7 ) and active ulcerative colitis patients ( 177.1 +/- 79.4 pg/mL vs. 87.4 +/- 77.2 pg/mL, P = 0.008, n = 9 ) ... IL-4 inhibited significantly the VEGF production by PBMCs of patients with inactive Crohn 's disease ( 179.2 +/- 133.9 pg/mL vs. 87.7 +/- 56.6 pg/mL, P = 0.005, n = 10 )
Trompezinski et al., Exp Dermatol 2002 : Taken together, these results indicate opposite effects of IFN-gamma and IL-4 on VEGF expression from normal and activated HF and HK
Lee et al., Mol Cells 2002 : Interleukin-4 inhibits the vascular endothelial growth factor- and basic fibroblast growth factor induced angiogenesis in vitro
Inoue et al., Rheumatol Int 2005 (Osteoarthritis, Hip...) : Induction of vascular endothelial growth factor and matrix metalloproteinase-3 ( stromelysin ) by interleukin-1 in human articular chondrocytes and synoviocytes
Faffe et al., Am J Respir Cell Mol Biol 2006 : Interleukin-13 and interleukin-4 induce vascular endothelial growth factor release from airway smooth muscle cells : role of vascular endothelial growth factor genotype ... IL-4 and IL-13 increased VEGF release and VEGF mRNA expression ... IL-4 also increased mRNA stability but did not affect VEGF promoter activity ... VEGF genotype at +405 or +936 alone had no effect on VEGF release, whereas cells bearing at least one -460C/-152A/+405G VEGF allele had lower release of VEGF in response to IL-13 or IL-4 than cells with other genotypes ... Our data suggest that IL-4 and IL-13 mediate their effects on VEGF expression post-transcriptionally and indicate that polymorphisms in the VEGF, but not the IL-4R alpha, gene affect VEGF release from smooth muscle cells
Hong et al., Clin Exp Immunol 2007 (Arthritis, Rheumatoid) : Effect of interleukin-4 on vascular endothelial growth factor production in rheumatoid synovial fibroblasts ... Because aberrant angiogenesis is a significant pathogenic component of tumour growth and chronic inflammation, we investigated the effect of IL-4 on the production of vascular endothelial growth factor ( VEGF ) by synovial fibroblasts derived from patients with rheumatoid arthritis ( RA ) ... In contrast, IL-4 exhibited the inhibitory effect on VEGF production when FLS were stimulated with TGF-beta ... Furthermore, exogenous addition of prostaglandin E2 ( PGE2 ) restored IL-4 inhibition on TGF-beta induced VEGF production
Huang et al., Am J Physiol Lung Cell Mol Physiol 2007 : IL-4 stimulates the expression of CXCL-8, E-selectin, VEGF , and inducible nitric oxide synthase mRNA by equine pulmonary artery endothelial cells
Shim et al., J Korean Med Sci 2008 : We investigated the effect of IL-4 and amphiregulin, an epidermal growth factor family member, on the proliferation of human ASM cells and on the release of vascular endothelial growth factor ( VEGF ) and monocyte chemotactic protein (MCP)-1 from human ASM cells ... IL-4 stimulated VEGF secretion by the ASM cells in a dose dependent manner and showed added stimulatory effects when co-incubated with PDGF
Bordin et al., Int J Oral Maxillofac Implants 2009 (Periodontitis) : Fibroblasts stimulated with TNF alpha showed increased levels of IL6, IL8, MCP1 ; neutrophil chemokine growth related oncogene alpha stimulation with IFN gamma increased MCP1 ; and stimulation with IL4 increased VEGF
Mohammadi et al., Iran J Immunol 2009 : Although VEGF production was dramatically suppressed by IL-4 , it was not dependent on VEGF genotype
Schmeding et al., Transplantation 2010 (Fatty Liver) : Analysis of liver enzymes, histology ( hematoxylin-eosin and periodic acid Schiff stain ), immunostaining ( terminal deoxynucleotide transferase- mediated dUTP nick-end labeling, hypoxyprobe, and tumor necrosis factor-alpha ), and reverse transcriptase-polymerase chain reaction of cytokine messenger RNA ( interleukin-1 , interleukin-6, hypoxia induced factor-1 alpha, vascular endothelial growth factor , and hepatocyte growth factor ) were performed at defined time points ( 2, 4.5, 24, 48 hr, and 7 days postoperatively )
Chew et al., BMC cancer 2010 (Nasopharyngeal Neoplasms...) : The present study examined the roles of EBV latent membrane protein-1 (LMP1), interleukin-6 (IL-6), interleukin-10 (IL-10), transforming growth factor-beta 1 ( TGF-ß1 ) and laminin in the regulation of matrix-metalloproteinases ( MMPs ) and vascular endothelial growth factor ( VEGF ) in NPC
Demyanets et al., Basic Res Cardiol 2011 (Atherosclerosis...) : Interferon-? ( IFN-? ), but not IL-4 or IL-10, reduced OSM induced VEGF production in vascular SMC
Choe et al., Joint Bone Spine 2012 (Arthritis, Rheumatoid...) : Tacrolimus ( FK506 ) inhibits interleukin-1ß induced angiopoietin-1, Tie-2 receptor, and vascular endothelial growth factor through down-regulation of JNK and p38 pathway in human rheumatoid fibroblast-like synoviocytes
Linde et al., J Pathol 2012 (Disease Models, Animal...) : However, VEGF-A alone is not sufficient to create a tumour promoting microenvironment and requires the presence of IL-4 and IL-10 to induce M2 polarization of macrophages
Byrne et al., PloS one 2013 (Airway Remodeling...) : Furthermore, HDM or IL-4 treatment of primary lung macrophages resulted in significant production of both VEGF-A and CXCL1 ; inhibition of HIF-1a activity abrogated the production of these factors via an up-regulation of PHD1 and PHD3
Ben-Av et al., FEBS Lett 1995 (Arthritis, Rheumatoid...) : Induction of vascular endothelial growth factor expression in synovial fibroblasts by prostaglandin E and interleukin-1 : a potential mechanism for inflammatory angiogenesis
Kvanta et al., Curr Eye Res 1995 : Both interleukin-1 and transforming growth factor beta induced VEGF expression in choroidal fibroblasts although with different time courses ... By using Western blotting, it was further found that stimulation with interleukin-1 induced VEGF protein expression in choroidal fibroblasts but not in RPE cells