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IL4 — TLR4
Text-mined interactions from Literome
Mita et al., Immunol Lett 2002
:
We examined the
regulation of
TLR4 surface expression in human peripheral blood monocytes and B cells by interleukin-2 (IL-2) and
IL-4 ... By contrast,
IL-4 down-regulated
TLR4 surface expression on human peripheral blood monocytes, but up-regulated TLR4 surface expression on human peripheral B cells
Askenase et al., J Immunol 2005
:
TLR dependent
IL-4 production by invariant Valpha14+Jalpha18+ NKT cells to initiate contact sensitivity in vivo
Fiset et al., Clin Exp Allergy 2006
:
To examine direct
effects of
IL-4 and STAT6 on
TLR4 expression of U-937 monocytic cells ...
TLR4 mRNA expression was
inhibited by
IL-4 as early as 6 h but the effect was lost by 24 h. Surface expression of TLR4 was inhibited by IL-4 at 12 and 24 h, but returned to baseline at 48 h. IL-4 inhibited activity of the TLR4 promoter as early as 6 h, but, like the mRNA, these effects were transient
Kramer et al., J Leukoc Biol 2006
(Crohn Disease) :
Moreover, they lack MDP induced enhancement of
TLR mediated tumor necrosis factor alpha,
interleukin (IL)-12 , and IL-10 production, which is observed in control DC with intact NOD2
Baruah et al., J Leukoc Biol 2006
:
C1q increases the phagocytosis of apoptotic cells by DC and the release of
interleukin-12 in the
presence of
TLR4 ligands and apoptotic cells ; PTX3 inhibits both events
Broad et al., Immunology 2007
:
In this study we have shown that, whilst NF-kappaB activation and production of TNF-alpha and
interleukin-12 by murine RAW264.7 and J774.2 cells in response to stimulation by TLR4, -5, -7 or -9, was
reduced by prior stimulation with
TLR4 , -5, -7 or -9 ligands, the primary stimulation of TLR3, which does not use the MyD88 pathway, did not reduce the TNF-alpha or interleukin-12 responses to subsequent TLR stimulation
Shen et al., Liver Transpl 2007
(Disease Models, Animal...) :
Disruption of
TLR4 signaling in OLTs decreased local neutrophil sequestration, CD4+ T cell infiltration, interferon (IFN)-gamma-inducible protein 10 ( CXCL10 ) and an intercellular adhesion molecule ( ICAM-1 ), as well as tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-2, and IFN-gamma, yet
increased IL-4 and IL-10 expression
Abdollahi-Roodsaz et al., Arthritis Rheum 2008
(Arthritis, Infectious...) :
Shift from toll-like receptor 2 (TLR-2) toward TLR-4 dependency in the erosive stage of chronic streptococcal cell wall arthritis coincident with
TLR-4 mediated
interleukin-17 production
Hammad et al., Nat Med 2009
(Asthma...) :
TLR4 triggering on structural cells
caused production of the innate proallergic cytokines thymic stromal lymphopoietin, granulocyte-macrophage colony stimulating factor,
interleukin-25 and interleukin-33
Marsh et al., J Neurosci 2009
(Infarction, Middle Cerebral Artery...) :
TLR4 can
induce both IFNbeta and interferon stimulated genes through its adapter molecule
Toll/interleukin receptor domain containing adaptor inducing IFNbeta ( TRIF ) and the IRF3 transcription factor
Lee et al., J Parasitol 2010
:
We also performed reverse transcriptase-polymerase chain reaction ( RT-PCR ) and flow cytometry to determine whether
TLR and MUC expression is
regulated by interferon (IFN)-gamma,
interleukin-4 , or monoclonal antibodies ( mAbs ) against G. seoi 46 kDa antigen ... We also performed reverse transcriptase-polymerase chain reaction ( RT-PCR ) and flow cytometry to determine whether
TLR and MUC expression is
regulated by interferon (IFN)-gamma,
interleukin-4 , or monoclonal antibodies ( mAbs ) against G. seoi 46 kDa antigen
Hutchinson et al., Neuroscience 2010
:
Live imaging of TLR4 activation in RAW264.7 cells and
TLR4 dependent
interleukin-1 release from BV-2 microglia revealed that amitriptyline blocked TLR4 signaling
Han et al., Vet Microbiol 2010
:
Involvement of
TLR21 in baculovirus induced
interleukin-12 gene expression in avian macrophage-like cell line HD11
Piconi et al., AIDS 2010
(HIV Infections) :
Activated T cells ( Ki67 ( + ) ), Treg lymphocytes ( CD4 ( + ) /CD25high/Foxp3+ ), divided into naive and activated cells based on PD1 expression,
interleukin (IL)-10 and transforming growth factor ( TGF ) -beta production, annexin V,
activation of caspases 8 and 9,
Toll-like receptor (TLR)2 and TLR4 expression on immune cells, and plasma lipopolysaccharide (LPS) concentration were analyzed
Chung et al., J Infect Dis 2010
(Hepatitis C, Chronic) :
Alloantigen presentation by monocytes isolated from HCV infected patients results in impaired production of
interleukin 17 by naive CD4 ( + ) T cells in the
presence of
TLR ligands
Hanamsagar et al., Trends Immunol 2012
:
TLR signaling
triggers the transcriptional activation of
pro-interleukin-1ß ( pro-IL-1ß ) and pro-IL-18 that are processed into their active forms by the inflammasome
Xia et al., J Pineal Res 2012
(Inflammation) :
As expected, melatonin inhibited
TLR4 mediated tumor necrosis factor alpha ( TNF-a ),
interleukin (IL)-1ß , IL-6, IL-8, and IL-10 in LPS stimulated macrophages
Villacres et al., J Infect Dis 2012
(HIV Infections...) :
Peripheral blood mononuclear cells ( PBMCs ) obtained at baseline were used to measure interleukin 1ß (IL-1ß),
interleukin 6 (IL-6), interleukin 10 (IL-10), interleukin 12 (IL-12), and tumor necrosis factor a (TNF-a)
responses to Toll-like receptor (TLR) 3 and
TLR4 stimulation
Li et al., eLife 2012
:
A sequence containing 13 nucleotides near the active site of 23S rRNA ribozyme, which catalyzes peptide bond synthesis, was both necessary and sufficient to trigger
TLR13 dependent
interleukin-1ß production
Koblansky et al., Immunity 2013
(Genetic Predisposition to Disease...) :
Toll-like receptor 11 ( TLR11 ) recognizes T. gondii profilin ( TgPRF ) and is
required for
interleukin-12 production and induction of immune responses that limit cyst burden in Toxoplasma gondii infected mice
Schamber-Reis et al., J Biol Chem 2013
(Disease Resistance...) :
Altogether, our results indicate the redundant and essential
role of nucleic acid sensing TLR3,
TLR7 and TLR9 in inducing
interleukin 12, development of a T1 response, and resistance to L. major infection in resistant C57BL/6 mice
Brancato et al., Wound Repair Regen 2013
(Disease Progression...) :
The accumulation of CCL2, CX3CL1, tumor necrosis factor-a,
interleukin (IL)-6 , IL-10, IL-12, and interferon-? in wound fluids was not
TLR4 dependent