Gene interactions and pathways from curated databases and text-mining

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CDC42 — PARD6A

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Hurd et al., Nat Cell Biol 2003 : The interaction between Par6 and PALS1 is direct, requires the amino terminus of PALS1 and the PDZ domain of Par6, and is regulated by Cdc42-GTP
Garrard et al., EMBO J 2003 : Cdc42 induces a conformational change in Par6 , detectable by fluorescence resonance energy transfer spectroscopy
Tzima et al., J Biol Chem 2003 : Thus, shear stimulated integrin dynamics induce polarized Cdc42 activity, which induces MTOC localization through the Par6-protein kinase Czeta complex
Hutterer et al., Dev Cell 2004 : Apical localization of Par-6 requires its interaction with activated Cdc42 and dominant-active or dominant negative Cdc42 disrupt epithelial polarity, suggesting that activation of this GTPase is crucial for the establishment of epithelial polarity
Liu et al., Mol Cell Biol 2004 : Coexpression of Par6 and ECT2 efficiently activated Cdc42 in vivo
Gao et al., J Biol Chem 2004 : These functional differences correlate with differences in Pals1 binding ; Par6B interacts strongly with Pals1, whereas Par6A binds weakly to Pals1 even in the presence of active Cdc42
Etienne-Manneville et al., J Cell Biol 2005 : Activation of the Par6-PKCzeta complex by Cdc42 at the leading edge of migrating cells promotes both the localized association of APC with microtubule plus ends and the assembly of Dlg containing puncta in the plasma membrane
Aceto et al., Dev Biol 2006 : We conclude that the CDC-42 interaction with PAR-6 is not required for the initial establishment of asymmetry but is required for maximal cortical accumulation of PAR-6 and to maintain its asymmetry
Atwood et al., J Cell Sci 2007 : Conversely, expression of constitutively active Cdc42 leads to ectopic Par-6-aPKC localization and corresponding cell polarity defects