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EPHB2 — LTB
Text-mined interactions from Literome
Klein et al., Cell Signal 2001
(MAP Kinase Signaling System) :
LPS, fMLP, and
LTB ( 4 )
stimulated similar levels of
ERK and Akt activation
Tong et al., Clin Cancer Res 2002
(Neoplasms, Experimental...) :
In contrast,
LTB4 stimulated proliferation of these cell lines and
induced ERK1/2 phosphorylation ... The growth-stimulatory effect and
ERK1/2 phosphorylation
induced by
LTB4 were inhibited by LY293111
Lee et al., Biochem Biophys Res Commun 2005
:
sPLA ( 2 ) -IB also stimulated mitogen activated protein kinase
ERK , but its activity was not
required for
LTB4 production
Tong et al., Biochem Biophys Res Commun 2005
(Pancreatic Neoplasms) :
The MEK inhibitors, PD98059 and U0126, blocked
LTB4 stimulated
ERK1/2 activation and cell proliferation
Profita et al., Allergy 2005
(Pulmonary Disease, Chronic Obstructive) :
The results obtained show that muscarinic receptors may be involved in airway inflammation in COPD subjects through ACh induced,
ERK1/2 dependent
LTB4 release
Sitrin et al., J Immunol 2006
:
Pretreating neutrophils with methyl-beta-cyclodextrin, a lipid raft disrupting agent, suppressed intracellular Ca ( 2+ ) mobilization and
ERK1/2 phosphorylation in
response to
LTB4 but had no effect on either of these responses to fMLP
Campos et al., Mol Immunol 2009
:
Endogenous
LTB ( 4 )
contributed to Fc gammaR mediated activation of PKC-alpha,
ERK 1/2 and PI3K, while endogenous cysLTs contributes to activation of PKC-delta, p38 and PI3K