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IL6 — IRAK4

Text-mined interactions from Literome

Kim et al., J Biol Chem 2005 (Inflammation) : Importantly, endogenous mPLK/IRAK was activated in response to TNF-alpha or interleukin 1 treatment of primary adipose cells
Peng et al., Ann N Y Acad Sci 2007 : Loss of IRAK4 largely blocked induction of IL-6
Song et al., Mol Immunol 2009 (Inflammation) : In contrast, an inhibitor of both IRAK-1 and IRAK-4 ( RO0884 ) reduced IL-1beta induced p38 MAP kinase, c-Jun N-terminal kinase activation, and IL-6 production in HUVEC
Chung et al., Immunity 2009 : IL-1 receptor1 expression in T cells, which was induced by IL-6 , was necessary for the induction of experimental autoimmune encephalomyelitis and for early Th17 cell differentiation in vivo
Eda et al., Cell Biol Int 2011 (Arthritis, Rheumatoid) : Interleukin-1ß induced interleukin-6 production in A549 cells is mediated by both phosphatidylinositol 3-kinase and interleukin-1 receptor associated kinase-4 ... These results indicate that IL-1ß induced IL-6 production in A549 cells is mediated by both PI3K and IRAK4 and suggest that involvement of PI3K in the IL-1 induced IL-6 production is cell type specific
Denis et al., Cell Immunol 1994 (Alveolitis, Extrinsic Allergic...) : Type-1 IL-1 receptor blockade did not directly alter the levels of tumor necrosis factor alpha in the lung homogenates, but it did lead to an interleukin-6 superinduction in the lungs
Schotanus et al., Endocrinology 1993 : We conclude that 1 ) IL-1 receptors are involved in the ACTH and IL-6 responses to rat IL-1 beta ; 2 ) the ACTH response, but not the IL-6 response, to a low dose dose of endotoxin in rats requires IL-1 receptor activation by endogenous produced IL-1 ; and 3 ) circulating IL-6 is not a prime mediator involved in ACTH and CORT responses to low doses of rIL-1 beta and endotoxin
Lacey et al., J Clin Invest 1993 : IL-1 induced murine osteoblast IL-6 production is mediated by the type 1 IL-1 receptor and is increased by 1,25 dihydroxyvitamin D3
Eriksson et al., Int J Mol Med 1998 : Since IL-1 is known to induce expression of both IL-1 and IL-6, we have investigated to what extent the induction of IL-1alpha and IL-6 by betaA25-35, is dependent on the IL-1 receptor type I (IL-1RI) , the only known signalling IL-1 receptor