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EGF — OAT

Text-mined interactions from Literome

Sauvant et al., American journal of physiology. Renal physiology 2004 : We conclude that 1 ) stimulation of basolateral organic anion uptake by EGF or PGE2 is a widespread ( if not general ) regulatory mechanism, 2 ) the signal transduction pathway involved seems to be general, 3 ) stimulation of basolateral organic anion uptake by EGF or PGE2 is also present under ex vivo conditions and, thus, is not a cell culture artifact, 4 ) activation of OAT1 is sufficient to explain the stimulatory effects of EGF and PGE2 in opossum kidney cells and rabbit S2 segments, and 5 ) stimulation of basolateral OAT1 by EGF or PGE2 is also important in humans and, thus, may have clinical implications
Soodvilai et al., American journal of physiology. Renal physiology 2005 : Previously, we showed that epidermal growth factor (EGF) stimulated OAT3 activity via the MAPK pathway ... In the present study, we investigated whether EGF stimulated OAT3 activity was dependent on tyrosine kinase and PI3K