Krappmann et al., Mol Cell Biol 2004
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The IkappaB kinase complex and NF-kappaB act as master regulators of lipopolysaccharide induced gene expression and control subordinate activation of AP-1 Greenberg et al., Alcohol 1998
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ETOH does not directly inhibit NFkappaB or AP-1 , in vivo, but rather inhibits LPS induced activation of the MEKK/MAP kinase system and inhibition of inhibitory protein IkappaBalpha required for formation of AP-1 and NFkappaB, respectively