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ICOSLG — TNF
Text-mined interactions from Literome
Yoshinaga et al., Int Immunol 2000
:
This ligand-receptor pair interacts with a K : ( D ) approximately 33 nM and an off-rate with a t ( ( 1/2 ) ) > 10 min. Interestingly,
tumor necrosis factor (TNF)-alpha differentially
regulates the expression of human
B7RP-1 on B cells, monocytes and dendritic cells ( DC ) ...
TNF-alpha enhances
B7RP-1 expression on B cells and monocytes, while it inhibits it on DC
Richter et al., J Biol Chem 2001
:
Induction of
ICOSL was
dependent on
TNF-alpha and was regulated via NF-kappa B as revealed by use of inhibitors specific for I kappa B alpha phosphorylation such as BAY 11-7082 and BAY 11-7085 ... Thus,
TNF-alpha induced
ICOSL expression seemed to be functionally important for the costimulatory capacity of CD34 ( + ) hematopoietic progenitor cells
Taylor et al., Blood 2005
(Graft vs Host Disease) :
ICOS ligand , a B7 family member, is constitutively expressed on B cells, macrophages, and dendritic cells and is
up-regulated on antigen presenting cells (APCs) and some nonlymphoid tissues by
tumor necrosis factor alpha (TNFalpha) or lipopolysaccharide (LPS)
Klingenberg et al., Eur J Immunol 2005
(Acute Disease) :
IL-1alpha and
TNF-alpha induced
ICOSL in an NF-kappaB dependent manner on human umbilical vein endothelial cells ( HUVEC )
de Haij et al., Kidney Int 2005
:
Stimulation with interferon-gamma (IFN-gamma) resulted in increased expression of B7-H1, whereas
ICOS-L expression was marginally
increased upon stimulation with CD40L, with no effect of interleukin ( IL-1 ), IL-17, or
tumor necrosis factor-alpha (TNF-alpha)
Qian et al., Eur J Immunol 2006
:
TNF-alpha significantly
induced B7-H2 and CD40 expression by A549 cells, but had no effect on B7-1 or B7-2 expression ... Monocyte derived
TNF-alpha in combination with IFN-gamma and LPS markedly
induced B7-H2 expression in A549 cells