Gene interactions and pathways from curated databases and text-mining

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ICOSLG — TNF

Text-mined interactions from Literome

Yoshinaga et al., Int Immunol 2000 : This ligand-receptor pair interacts with a K : ( D ) approximately 33 nM and an off-rate with a t ( ( 1/2 ) ) > 10 min. Interestingly, tumor necrosis factor (TNF)-alpha differentially regulates the expression of human B7RP-1 on B cells, monocytes and dendritic cells ( DC ) ... TNF-alpha enhances B7RP-1 expression on B cells and monocytes, while it inhibits it on DC
Richter et al., J Biol Chem 2001 : Induction of ICOSL was dependent on TNF-alpha and was regulated via NF-kappa B as revealed by use of inhibitors specific for I kappa B alpha phosphorylation such as BAY 11-7082 and BAY 11-7085 ... Thus, TNF-alpha induced ICOSL expression seemed to be functionally important for the costimulatory capacity of CD34 ( + ) hematopoietic progenitor cells
Taylor et al., Blood 2005 (Graft vs Host Disease) : ICOS ligand , a B7 family member, is constitutively expressed on B cells, macrophages, and dendritic cells and is up-regulated on antigen presenting cells (APCs) and some nonlymphoid tissues by tumor necrosis factor alpha (TNFalpha) or lipopolysaccharide (LPS)
Klingenberg et al., Eur J Immunol 2005 (Acute Disease) : IL-1alpha and TNF-alpha induced ICOSL in an NF-kappaB dependent manner on human umbilical vein endothelial cells ( HUVEC )
de Haij et al., Kidney Int 2005 : Stimulation with interferon-gamma (IFN-gamma) resulted in increased expression of B7-H1, whereas ICOS-L expression was marginally increased upon stimulation with CD40L, with no effect of interleukin ( IL-1 ), IL-17, or tumor necrosis factor-alpha (TNF-alpha)
Qian et al., Eur J Immunol 2006 : TNF-alpha significantly induced B7-H2 and CD40 expression by A549 cells, but had no effect on B7-1 or B7-2 expression ... Monocyte derived TNF-alpha in combination with IFN-gamma and LPS markedly induced B7-H2 expression in A549 cells