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ADAMTS5 — TNF

Text-mined interactions from Literome

Bevitt et al., Biochim Biophys Acta 2003 : The expression of ADAMTS genes in ARPE-19 cells and the transcriptional stimulation of some family members by TNFalpha may implicate them in inflammatory eye disease and the compromise of retinal matrix structure, which is evident in age related macular degeneration ( ARMD ) and other retinal pathologies
Voigt et al., Arthritis Res Ther 2009 : TNFalpha increased matrix metalloproteinase (MMP)-3 and a disintegrin and metalloproteinase with thrombospondin motifs ( ADAMTS)-4 mRNA expression, whereas collagen type I was decreased, and aggrecan, collagen type II as well as MMP-1, -2, -13 and ADAMTS-5 were variably affected
Tian et al., Am J Pathol 2013 (Intervertebral Disc Degeneration) : Lentiviral transduction with shRNA plasmids shp65, shp52, shIKK-a, and shIKK-ß significantly decreased TNF-a dependent increase in ADAMTS-4 and -5 levels and aggrecan degradation