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ANPEP — PRKAG1
Text-mined interactions from Literome
Wang et al., Am J Physiol Endocrinol Metab 2009
(Reperfusion Injury) :
Collectively, our present study demonstrated that although the metabolic and eNOS activation effect of
APN is largely
mediated by
AMPK , the superoxide suppressing effect of APN is not mediated by AMPK, and this AMPK independent antioxidant property of APN increased nitric oxide bioavailability and exerted significant antiapoptotic effect
Lin et al., Am J Pathol 2010
(Drug-Induced Liver Injury...) :
Furthermore,
AMPK mediated peroxisome proliferator activated receptor-a ( PPARa ) activation by
APN was ascribable to HO-1 induction
Denzel et al., J Clin Invest 2010
(Cardiomegaly...) :
In both cardiac hypertrophy and ischemia-reperfusion models, T-cadherin was necessary for
APN dependent
AMPK phosphorylation ... In APN-null mice, recombinant adenovirus expressed
APN reduced exaggerated hypertrophy and infarct size and
restored AMPK phosphorylation as previously reported
Essick et al., Am J Physiol Heart Circ Physiol 2011
(Cardiomegaly...) :
APN significantly
increased p-AMPK in both nonstimulated and H ( 2 ) O ( 2 ) -treated ARVM
Yan et al., Basic Res Cardiol 2013
(Diabetes Complications...) :
Since
APN is an upstream
activator of
AMPK and APN plasma levels are significantly reduced in ob/ob mice, we further tested the hypothesis that reduced APN in ob/ob mice is causatively related to mitochondrial biogenesis impairment
Guo et al., Biochim Biophys Acta 2013
(Cardiomegaly...) :
Furthermore,
APN deficiency
augmented high fat diet induced upregulation in the autophagy adaptor p62 and the decline in
AMPK without affecting high fat diet induced decrease in LC3II and LC3II-to-LC3I ratio