Gene interactions and pathways from curated databases and text-mining

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ANPEP — PRKAG1

Text-mined interactions from Literome

Wang et al., Am J Physiol Endocrinol Metab 2009 (Reperfusion Injury) : Collectively, our present study demonstrated that although the metabolic and eNOS activation effect of APN is largely mediated by AMPK , the superoxide suppressing effect of APN is not mediated by AMPK, and this AMPK independent antioxidant property of APN increased nitric oxide bioavailability and exerted significant antiapoptotic effect
Lin et al., Am J Pathol 2010 (Drug-Induced Liver Injury...) : Furthermore, AMPK mediated peroxisome proliferator activated receptor-a ( PPARa ) activation by APN was ascribable to HO-1 induction
Denzel et al., J Clin Invest 2010 (Cardiomegaly...) : In both cardiac hypertrophy and ischemia-reperfusion models, T-cadherin was necessary for APN dependent AMPK phosphorylation ... In APN-null mice, recombinant adenovirus expressed APN reduced exaggerated hypertrophy and infarct size and restored AMPK phosphorylation as previously reported
Essick et al., Am J Physiol Heart Circ Physiol 2011 (Cardiomegaly...) : APN significantly increased p-AMPK in both nonstimulated and H ( 2 ) O ( 2 ) -treated ARVM
Yan et al., Basic Res Cardiol 2013 (Diabetes Complications...) : Since APN is an upstream activator of AMPK and APN plasma levels are significantly reduced in ob/ob mice, we further tested the hypothesis that reduced APN in ob/ob mice is causatively related to mitochondrial biogenesis impairment
Guo et al., Biochim Biophys Acta 2013 (Cardiomegaly...) : Furthermore, APN deficiency augmented high fat diet induced upregulation in the autophagy adaptor p62 and the decline in AMPK without affecting high fat diet induced decrease in LC3II and LC3II-to-LC3I ratio