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Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Hoberg et al., Mol Cell 2004
:
Here, we demonstrate that NF-kappaB transcription
requires IKKalpha to phosphorylate
SMRT on chromatin, stimulating the exchange of corepressor for coactivator complexes ... Failure of
IKKalpha to
stimulate the removal of
SMRT from chromatin inhibits the recruitment of NF-kappaB to promoters, blocking transcription and sensitizing cells to apoptosis
Hoberg et al., Mol Cell Biol 2006
:
Introduction of nonphosphorylatable mutants of RelA/p65 and
SMRT proteins or the
inhibition of
IKK activity results in active repression of NF-kappaB promoters by tethering the SMRT-HDAC3 complex
Karmakar et al., Mol Endocrinol 2010
(Breast Neoplasms) :
SMRT and SRC-3 bind directly in an ERalpha independent manner, and this interaction
promotes E2-dependent
SRC-3 binding to ERalpha measured by co-IP and SRC-3 recruitment to the cyclin D1 gene as measured by chromatin IP assays