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IRAK4 — IRF6

Text-mined interactions from Literome

Yamashina et al., Biochem Biophys Res Commun 2000 : In Kupffer cells from mice treated with ethanol 1 h earlier, LPS induced TNFalpha production, and IRAK expression and activity and NFkappaB were decreased 50-60 % of control
Ferlito et al., J Leukoc Biol 2001 (Leukemia, Monocytic, Acute...) : LPS stimulation induced production of TNF-alpha or TxB2 and degradation of IRAK
Bannerman et al., J Biol Chem 2002 : Using a variety of dominant negative constructs, we have identified a role for MyD88 and interleukin-1 receptor associated kinase-1 ( IRAK-1 ) in mediating LPS pro-apoptotic signaling in human endothelial cells
Taggart et al., J Biol Chem 2002 : We have also demonstrated that SLPI prevents LPS induced interleukin-1 receptor associated kinase and IkappaBbeta degradation
Sato et al., Int Immunol 2002 : In contrast, mycoplasmal lipopeptides did not affect the MyD88 independent pathway, but impaired the MyD88 dependent signaling by inhibiting LPS mediated activation of IL-1 receptor associated kinase (IRAK) 1
Ferlito et al., J Endotoxin Res 2002 : Neither PTx nor PP2 inhibited LPS induced activation of interleukin receptor activated kinase ( IRAK ) or inhibited translocation of NF-kappaB
Xing et al., Shock 2003 (Inflammation) : On a per cell basis, LPS induced TNF-soluble receptor type II and IL-1 receptor antagonist production by PMNs was 9.8 % and 15.4 % of those of PBMCs, respectively
Yamashina et al., Nihon Arukoru Yakubutsu Igakkai Zasshi 2003 (Liver Diseases, Alcoholic) : In contrast, in Kupffer cells from mice treated with ethanol 21 hours earlier, LPS induced TNF alpha production, expression and activity of IRAK were increased 1.5-fold over controls, while NF kappa B activation was elevated 3-fold
Asehnoune et al., J Immunol 2004 : Activation of IL-1R associated kinase-1 (IRAK-1) and IRAK-4 in response to LPS stimulation was inhibited by antioxidants
Noubir et al., J Biol Chem 2004 : Lipopolysaccharide (LPS) signaling leading to nuclear factor-kappaB activation in mononuclear phagocytes involves interleukin-1 receptor associated kinase ( IRAK ), which is rapidly activated after exposure to agonist
Cuschieri et al., Cell Immunol 2004 : LPS stimulation led to the phosphorylation and degradation of IRAK , followed by activation of JNK/SAPK, ERK 1/2, and p38 ... Proteasome inhibition with either lactacystin or MG-132 attenuated LPS induced IRAK degradation, and enhanced activation of JNK/SAPK, ERK 1/2, and p38
Carl et al., J Leukoc Biol 2004 : Role of endogenous IL-10 in LPS induced STAT3 activation and IL-1 receptor antagonist gene expression
Frost et al., Am J Physiol Cell Physiol 2004 (MAP Kinase Signaling System) : LPS transiently stimulated the phosphorylation of the interleukin-1 receptor associated kinase ( IRAK-1 ) in C ( 2 ) C ( 12 ) cells and decreased the total amount of IRAK-1 both in vitro and in vivo over time
Cuschieri et al., J Surg Res 2004 : LPS stimulation led to the mobilization of TLR4 to lipid rafts followed by phosphorylation and activation of IRAK , ERK 1/2, p38, and JNK/SAPK
Li et al., J Leukoc Biol 2006 : Furthermore, decreased MyD88-IRAK immunocomplex formation, as demonstrated by immunoprecipitation, was observed in BLP-tolerant cells following a second BLP or LPS stimulation
Pacquelet et al., Biochem J 2007 : IRAK-4 phosphorylated p47phox activated the NADPH oxidase in a cell-free system, and IRAK-4 overexpression increased NADPH oxidase activity in response to LPS ... IRAK-4 was activated in neutrophils in response to LPS stimulation
Sebai et al., Arch Biochem Biophys 2010 : LPS increased CD14 expression ; IRAK1 and a phosphorylated form of p38 MAPK protein
Reis et al., Cell Biochem Biophys 2011 : TNF-a is induced by LPS in the LMP knockout macrophages because I?B and IRAK are degraded normally via the MyD88 pathway
Lee et al., J Agric Food Chem 2012 (Colitis...) : Ginsenoside Re also inhibited IRAK-1 phosphorylation induced by LPS , as well as IRAK-1 and IRAK-4 degradations in LPS stimulated peritoneal macrophages
Smith et al., J Immunol 1994 : LPS induced expression of the human IL-1 receptor antagonist gene is controlled by multiple interacting promoter elements
Saccani et al., Cytokine 1998 : Divergent effects of LPS on expression of IL-1 receptor family members in mononuclear phagocytes in vitro and in vivo