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IL2RA — PTBP2
Text-mined interactions from Literome
Mehlhop et al., J Immunol Methods 2002
(Simian Acquired Immunodeficiency Syndrome) :
In general, macaque
DCs exhibited weaker responses to LPS and Poly I:C than human DCs, and soluble CD40L stimulation
induced variable expression of
CD25
Gorczynski et al., Transplantation 2005
:
In the presence of anti-CD200R2/3 monoclonal antibodies ( mAbs ), bone-marrow cells cultured in the presence of ( interleukin [IL]-4+granulocyte-macrophage colony stimulating factor ) differentiate into
dendritic cells (DCs) , which
induce CD4CD25Treg
Ahn et al., Int Immunol 2007
:
We sought to characterize the
effects of
dendritic cells (DCs) on the in vitro regulatory activity of CD4 ( + )
CD25 ( + ) T cells obtained from peripheral blood of healthy human donors
Luo et al., Proc Natl Acad Sci U S A 2007
(Diabetes Mellitus, Type 1) :
Here we show that beta-cell peptide pulsed
dendritic cells (DCs) from nonobese diabetic ( NOD ) mice can effectively
induce CD4 ( + )
CD25 ( + ) Foxp3 ( + ) T cells from naïve islet-specific CD4 ( + ) CD25 ( - ) T cells in the presence of TGF-beta1 ... These results indicate a
role for
DCs in the induction of antigen-specific CD4 ( + )
CD25 ( + ) Foxp3 ( + ) T cells that can inhibit fully developed autoimmunity in a nonlymphopoenic host, providing an important potential strategy for immunotherapy in patients with autoimmune diabetes
Torisu et al., J Gastroenterol 2008
(Autoimmune Diseases...) :
Taken together, these results suggest that increased
induction of CD4 ( + )
CD25 ( + ) regulatory T cells by
Reg-DCs might contribute to downregulation of inflammatory processes and autoantibody production during AIG development in mice
Silva-Campa et al., Virology 2009
(Porcine Reproductive and Respiratory Syndrome) :
Our results showed that PRRSV infected
DCs significantly
increased Foxp3 ( + )
CD25 ( + ) T cells, an effect that was reversible by IFN-alpha treatment, and this outcome was reproducible using two distinct PRRSV strains
Mnasria et al., Transplant Proc 2009
(Acute Disease) :
In this study, we observed that stimulation of human monocyte derived
DCs with lipopolysa ccharide or CD40L strongly
induced the expression of
CD25
Brenk et al., J Immunol 2009
:
Moreover, ILT3 ( high ) ILT4 ( high )
DCs lead to the induction of CD4 ( + )
CD25 ( + ) Foxp3 ( + ) T regulatory cells with suppressive activity from CD4 ( + ) CD25 ( - ) T cells
Zhu et al., J Interferon Cytokine Res 2009
:
DCs treated with HMGB1 ( 1 microg/mL for 48 h ) promoted T-cell proliferation as well as differentiation, and markedly
up-regulated IL-2,
IL-2R expression and intranuclear NF-kappaB activation
Zhou et al., Clin Dev Immunol 2010
:
These results suggested that lactadherin could adjust intestinal
DCs activity,
induce CD3 ( + ) CD4 ( + )
CD25 ( + ) T cell differentiation, and enhance IL-10 production
Pothoven et al., Am J Transplant 2010
:
This work addresses whether rapamycin conditioned donor
DCs could effectively
induce CD4 ( + )
CD25 ( + ) Foxp3 ( + ) Tregs ( iTregs ) in cell cultures with alloantigen specificities, and whether such in vitro differentiated CD4 ( + ) CD25 ( + ) Foxp3 ( + ) iTregs could effectively control acute rejection in allogeneic islet transplantation
Nishimura et al., Xenotransplantation 2010
:
Porcine cell pulsed
DCs stimulated CD4 ( + ) T cells, and CD4 ( + )
CD25 ( + ) regulatory T cells
suppressed this response
Zhao et al., Eur J Cancer 2012
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
CML-MSC-DCs derived TGF-ß1 was largely
responsible for the increase in
CD4+CD25+Foxp3+Tregs based on knockdown studies
Cecere et al., Vet Microbiol 2012
(Coinfection...) :
DCs infected with PCV2 significantly
increased CD4 ( + )
CD25 ( + ) FoxP3 ( + ) T ( regs ) ( p < 0.05 ) and DCs co-infected with PRRSV and PCV2 induced significantly higher numbers of T ( regs ) than with PCV2 alone ( p < 0.05 )
Ramos et al., J Leukoc Biol 2012
(Breast Neoplasms) :
In cancer,
DCs may
play a dysfunctional role in the induction of CD4 ( + )
CD25 ( + ) Foxp3 ( + ) Tregs, contributing to immune evasion