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MTX1 — RELA
Text-mined interactions from Literome
Majumdar et al., J Immunol 2001
:
We investigated the
effects of
MTX on
NF-kappaB activation induced by TNF in Jurkat cells ... Besides TNF,
MTX also
suppressed the
NF-kappaB activation induced by various other inflammatory stimuli ... A partial reversal of
MTX induced
NF-kappaB suppression by thymidine and folinic acid indicates the role of the thymidylate synthase pathway also ... Overall, our results clearly demonstrate that
MTX suppresses
NF-kappaB activation through the release of adenosine, which may contribute to the role of MTX in anti-inflammatory, immunomodulatory, and antiproliferative effects
Yozai et al., J Am Soc Nephrol 2005
(Albuminuria...) :
MTX also
reduced the high glucose induced
NF-kappaB activation in vitro and in vivo
Logan et al., Cancer Chemother Pharmacol 2009
(Mucositis) :
Both
MTX and 5-FU administration
caused histological evidence of tissue damage in the AT as well as changes in tissue expression of
NF-kappaB and specific pro-inflammatory cytokines
Chang et al., Anticancer Res 2009
(Liver Neoplasms, Experimental) :
The luciferase expression by BLI assay reflected that the TPA induced
NF-kappaB activity was
suppressed by
MTX after 16 h treatment ... BLI directly revealed that
MTX inhibited cellular transformation by
suppressing NF-kappaB activity