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ESR1 — MED1
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
ESR1
→
MED1
(directlyIncreases, MED1 Activity)
Evidence: and the p160 family, a wide spectrum In addition to the chromatin remodeling complexes of coactivators has been found to interact with ER. These include DRIP205/ TRAP220/PBP, a component of the DRIP/TRAP mediator complex [39-41], PGC-1, a tissue- and promoter-specific PPARgamma-coactivator-1 [42,43], SNURF, a small nuclear C(3)HC(4) finger protein [44], PELP1, a proline-, glutamic acid-, leucine-rich protein 1 [45], and NCoA-7 (ERAP140), a structurally distinct coactivator [46].
-
NCI Pathway Database Validated nuclear estrogen receptor alpha network:
MED1 (MED1)
→
E2/ERA (dimer) complex (ESR1)
(modification, collaborate)
Fujita et al., J Biol Chem 2003*, Wu et al., J Biol Chem 2004*
Evidence: physical interaction
-
NCI Pathway Database Validated nuclear estrogen receptor alpha network:
MED1 (MED1)
→
E2/ERA (dimer)/MED1 complex (ESR1-MED1)
(modification, collaborate)
Fujita et al., J Biol Chem 2003*, Wu et al., J Biol Chem 2004*
Evidence: physical interaction
-
NCI Pathway Database Validated nuclear estrogen receptor alpha network:
E2/ERA (dimer) complex (ESR1)
→
E2/ERA (dimer)/MED1 complex (ESR1-MED1)
(modification, collaborate)
Fujita et al., J Biol Chem 2003*, Wu et al., J Biol Chem 2004*
Evidence: physical interaction
-
Reactome Reaction:
ESR1
→
MED1
(reaction)
Rachez et al., Nature 1999, Jepsen et al., J Cell Sci 2002, Bourbon et al., Mol Cell 2004, Malik et al., Trends Biochem Sci 2005, Rosenfeld et al., Genes Dev 2006, Yuan et al., Proc Natl Acad Sci U S A 1998
-
Reactome Reaction:
ESR1
→
MED1
(direct_complex)
Rachez et al., Nature 1999, Jepsen et al., J Cell Sci 2002, Bourbon et al., Mol Cell 2004, Malik et al., Trends Biochem Sci 2005, Rosenfeld et al., Genes Dev 2006, Yuan et al., Proc Natl Acad Sci U S A 1998
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind_translation Interaction:
MED1
—
ESR1
(affinity chromatography technology)
Fujita et al., J Biol Chem 2003*
-
IRef Bind_translation Interaction:
MED1
—
ESR1
(two hybrid)
Fujita et al., J Biol Chem 2003*
-
IRef Biogrid Interaction:
MED1
—
ESR1
(direct interaction, pull down)
Llopis et al., Proc Natl Acad Sci U S A 2000*
-
IRef Biogrid Interaction:
MED1
—
ESR1
(direct interaction, fluorescent resonance energy transfer)
Llopis et al., Proc Natl Acad Sci U S A 2000*
-
IRef Biogrid Interaction:
MED1
—
ESR1
(direct interaction, pull down)
Fujita et al., J Biol Chem 2003*
-
IRef Biogrid Interaction:
MED1
—
ESR1
(direct interaction, two hybrid)
Fujita et al., J Biol Chem 2003*
-
IRef Biogrid Interaction:
MED1
—
ESR1
(physical association, affinity chromatography technology)
Kitagawa et al., Cell 2003
-
IRef Biogrid Interaction:
MED1
—
ESR1
(physical association, affinity chromatography technology)
Kang et al., Proc Natl Acad Sci U S A 2002
-
IRef Biogrid Interaction:
MED1
—
ESR1
(direct interaction, pull down)
Kang et al., Proc Natl Acad Sci U S A 2002
-
IRef Biogrid Interaction:
MED1
—
ESR1
(direct interaction, pull down)
Wada-Hiraike et al., Br J Cancer 2005*
-
IRef Biogrid Interaction:
MED1
—
ESR1
(direct interaction, pull down)
Burakov et al., J Biol Chem 2000*
-
IRef Biogrid Interaction:
MED1
—
ESR1
(direct interaction, two hybrid)
Burakov et al., J Biol Chem 2000*
-
IRef Biogrid Interaction:
MED1
—
ESR1
(physical association, affinity chromatography technology)
Burakov et al., J Biol Chem 2000*
-
MIPS CORUM TFTC-type histone acetyl transferase complex:
TFTC-type histone acetyl transferase complex complex (ESR1-KAT2A-MED1-MED12-MED13-MED14-MED16-MED17-MED23-MED24-TRRAP)
Yanagisawa et al., Mol Cell 2002
-
IRef Corum Interaction:
Complex of 34 proteins
(association, cosedimentation through density gradient)
Yanagisawa et al., Mol Cell 2002
-
IRef Intact Interaction:
MED1
—
ESR1
(physical association, pull down)
Yuan et al., Proc Natl Acad Sci U S A 1998
-
IRef Intact Interaction:
Complex of 143 proteins
(association, cosedimentation through density gradient)
Nassa et al., Proteomics 2011
-
IRef Ophid Interaction:
MED1
—
ESR1
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Acevedo et al., Mol Cell Biol 2003
:
We have used a biochemical approach, including an in vitro chromatin assembly and transcription system, to examine the functional
role for
Mediator in the transcriptional activity of
estrogen receptor alpha (ERalpha) with chromatin templates, as well as functional interplay between Mediator and p300/CBP during ERalpha dependent transcription ... Using three different approaches to functionally inactivate Mediator ( immunoneutralization, immunodepletion, and inhibitory polypeptides ), we find that
Mediator is
required for maximal transcriptional activation by ligand activated
ERalpha
Leite et al., J Neuroendocrinol 2008
:
ERalpha expression in TH-ir neurones
increased at 14 and 16 h in the
rostral-ARC and dorsomedial-ARC, 14 h in the caudal-ARC and 16 h in the VMPO, whereas it was unaltered in the ventrolateral-ARC, periventricular and AVPe