◀ Back to CCL2
CCL2 — CD46
Text-mined interactions from Literome
Sharma et al., Am J Physiol Lung Cell Mol Physiol 2007
(Inflammation...) :
H/R ( 3 h/1 h ) significantly
induced KC,
MCP-1 , macrophage inflammatory protein-2 ( MIP-2 ), RANTES, and IL-6 ( but not TNF-alpha ) by MLE-12 cells, whereas H/R induced TNF-alpha,
MCP-1 , RANTES, MIP-1alpha, and MIP-2 ( but not KC ) by RAW264.7 cells
Buntinx et al., J Pharmacol Exp Ther 2008
(Encephalomyelitis, Autoimmune, Experimental) :
JNJ-27141491 strongly suppressed hCCR2 mediated in vitro functions, such as
MCP-1 induced guanosine 5'-O- ( 3- [ ( 35 ) S ] thio ) triphosphate binding
; MCP-1 , -3, and -4-induced Ca ( 2+ ) mobilization ; and leukocyte chemotaxis toward MCP-1 ( IC ( 50 ) = 7-97 nM ), whereas it had little or no effect on the function of other chemokine receptors tested
Vrotsos et al., Brain Res Bull 2009
(MAP Kinase Signaling System) :
The binding of
MCP-1 to its chemokine receptor
induces expression of novel transcription factor
MCP-1 induced protein (MCPIP)
Tarabra et al., Diabetes 2009
(Diabetes Mellitus, Experimental...) :
In experimental diabetes,
MCP-1 was overexpressed within the glomeruli and the absence of
MCP-1 reduced both albuminuria and downregulation of nephrin and synaptopodin
Iglesias-Gato et al., Phytother Res 2012
(Inflammation) :
Additionally, Prostasanr reduced the constitutive secretion of
monocyte chemotactic protein-1 (MCP-1) , the LPS induced secretion of IL-12 and
inhibited MCP-1 and granulocyte-macrophage colony stimulating factor ( GM-CSF ) production in the presence of LPS on PC-3 cells
Kim et al., Mol Med Report 2013
:
Monocyte chemotactic protein-1 (MCP-1)/CCL2 , interleukin (IL)-6 and IL-8
increased following DpE treatment and arazyme significantly blocked the increase of
MCP-1 , IL-6 and IL-8 expression in cell types