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COMP — SOX9

Text-mined interactions from Literome

Liu et al., Frontiers in bioscience : a journal and virtual library 2007 : Transcriptional activation of cartilage oligomeric matrix protein by Sox9 , Sox5, and Sox6 transcription factors and CBP/p300 coactivators ... Sox9 activates COMP gene expression and this activation is PRE dependent ... Sox9 is required for COMP gene expression during chondrogenesis, since repression of Sox9 expression using the small interfering RNA approach inhibited COMP gene expression ... In addition, activation of COMP gene expression by Sox9 requires the participation of transcription factors Sox5 and Sox6 as well as the coactivators CBP and p300 histone acetylase
Hanley et al., J Biol Chem 2008 (Fibrosis) : In human fetal hepatocytes, this aberrant induction of SOX9 protein caused ectopic expression of COL2A1 and COMP1 that encode extracellular matrix ( ECM ) components normally associated with chondrogenesis