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IL2 — IL8
Text-mined interactions from Literome
van Milligen de Wit et al., Eur J Gastroenterol Hepatol 1999
(Cholangitis, Sclerosing) :
Baseline serum levels of interleukin-6 (IL-6) and soluble
IL-2 receptor were normal, and serum
IL-8 levels were
increased , but none of these variables was significantly affected by UDCA therapy
Liu et al., Zhongguo Zhong Xi Yi Jie He Za Zhi 1997
(Yang Deficiency) :
Hemorheological indexes, brain noradrenaline ( NE ), adrenocorticotropine ( ACTH ), beta endorphin, cortisol, estradiol, testosterone,
interleukin-II (IL-2), tumour necrosis factor (TNF) in the blood, and rat spleen 's lymphocyte transformation and
induction of
IL-2 and the activity of natural killer cells ( NKC )
Song et al., Neuroscience 1999
:
As well,
interleukin-6 and interleukin-2 were both found to reduce the homovanillic acid response associated with the stress, and
interleukin-2 promoted a decline of homovanillic acid levels
Greene et al., Biochim Biophys Acta 1999
:
Interleukin-1 receptor associated kinase and TRAF-6 mediate the transcriptional
regulation of
interleukin-2 by
interleukin-1 via NFkappaB but unlike interleukin-1 are unable to stabilise interleukin-2 mRNA
Bosco et al., J Immunol 2000
(Inflammation) :
Furthermore, HA markedly suppressed the ability of
IL-2 to
induce IL-1 beta, TNF-alpha, IL-6, and
IL-8 mRNA expression and protein secretion by monocytes
Matsuura et al., Dig Liver Dis 2000
(Crohn Disease) :
The effect of interleukin-4 on lamina propria mononuclear cells from Crohn 's disease, ulcerative colitis and control mucosa was assessed on various T-cell functions
: interleukin-2 induced cytotoxicity, soluble
interleukin-2 receptor and interleukin-2 production, and expression of mRNA for interleukin-2R and interferon-gamma
Kelley et al., Lipids 2001
:
CLA supplementation did not alter the in vitro secretion of prostaglandin E2, leukotriene B4,
interleukin-1beta (IL-1beta), or tumor necrosis factor alpha (TNFalpha) by PBMC simulated with lipopolysaccharide, and the secretion of
IL-2 by PBMC
stimulated with phytohemagglutinin
Lottaz et al., J Invest Dermatol 2001
:
We hypothesize that inhibition of this pathway prevents secretion of interleukin-1, thereby downregulating
interleukin-1 dependent autocrine induction of
interleukin-8
Prause et al., Eur J Pharmacol 2003
:
Pharmacological modulation of
interleukin-17 induced GCP-2-, GRO-alpha- and
interleukin-8 release in human bronchial epithelial cells ... We found that
interleukin-17 ( 1-1000 ng/ml )
increased the release of GCP-2, GRO-alpha and
interleukin-8 in a concentration dependent manner
Waehre et al., J Am Coll Cardiol 2003
(Coronary Artery Disease) :
Our main findings were : 1 ) gene expression of several chemokines ( i.e., macrophage inflammatory protein [MIP ] -1alpha, MIP-1beta, and
interleukin [ IL]-8 ) and chemokine receptors ( i.e., CC chemokine receptor [ CCR]1, CCR2, CCR4, and CCR5 ) was markedly increased among CAD patients compared with healthy control subjects ; 2 ) treatment with atorvastatin and simvastatin markedly reduced the mRNA levels of some of these chemokines ( i.e., MIP-1alpha, MIP-1beta, IL-8 ) and receptors ( i.e., CCR1 and CCR2 ), with the most pronounced effect in the atorvastatin group ; and 3 ) statin therapy
reduced the spontaneous release of
IL-8 and MIP-1alpha from PBMCs in CAD patients
Dalhoff et al., Lancet Infect Dis 2003
:
In general, most fluoroquinolone derivatives superinduce in-vitro
interleukin 2 synthesis but
inhibit synthesis of
interleukin 1 and tumour necrosis factor (TNF)alpha ; furthermore, they enhance significantly the synthesis of colony stimulating factors (CSF)
Vittori et al., J Allergy Clin Immunol 1992
:
Protective effect of nedocromil sodium on the
interleukin-1 induced production of
interleukin-8 in human bronchial epithelial cells
Uchiyama et al., Am J Obstet Gynecol 1992
:
These results indicate that
interleukin-8-like chemotactic factor participates in the cervical ripening at term pregnancy and that the production of this factor is
controlled effectively by
interleukin-1
Soloff et al., Endocrinology 2004
:
In situ analysis of
interleukin-1 induced transcription of cox-2 and
il-8 in cultured human myometrial cells
Wuyts et al., J Heart Lung Transplant 2004
:
N-acetylcysteine inhibits
interleukin-17 induced
interleukin-8 production from human airway smooth muscle cells : a possible role for anti-oxidative treatment in chronic lung rejection ?
Ozawa et al., J Immunol 2004
(Periodontitis) :
Exogenous
IL-2 and IL-15
induced production of MCP-1 but not
IL-8 in normal HGF, and induced the production of both chemokines in inflamed HGF
Hirota et al., Rheumatol Int 1992
:
Production of
interleukin 8 by cultured synovial cells in
response to
interleukin 1 and tumor necrosis factor
Hashmi et al., Coron Artery Dis 2006
(Angina, Unstable) :
Role of interleukin-17 and
interleukin-17 induced cytokines interleukin-6 and
interleukin-8 in unstable coronary artery disease
Lambert et al., J Biol Chem 2007
(Respiratory Tract Infections) :
The alpha, beta unsaturated aldehydes in cigarette smoke ( acrolein and crotonaldehyde ) inhibited production of
interleukin-2 (IL-2) , IL-10, granulocyte-macrophage colony stimulating factor, interferon-gamma, and tumor necrosis factor-alpha by human T cells but did not
inhibit production of
IL-8
Fernández et al., Appl Environ Microbiol 2007
:
Furthermore, expression of a mature mouse
IL-2 gene
resulted in
interleukin secretion without the requirement for a leader sequence
Darbonne et al., J Clin Invest 1991
:
Their binding of IL-8 is rapidly reversible and does not result in receptor internalization, although bound IL-8 is resistant to extraction by pH 3 buffer at 5 degrees C.
125I-IL-8 binding to red cells was not
inhibited by epidermal growth factor or
interleukin 1, but was inhibited by monocyte chemotactic peptide-1, which is not a neutrophil chemotaxin, but is a member of the same family of polypeptides as IL-8
Tomizawa et al., Clin Exp Immunol 1991
:
Of the cytokines studied,
interleukin-4 (IL-4) and interferon-gamma (IFN-gamma) were
involved in the regulation of
IL-2R on B cells
Larsen et al., Biochem Biophys Res Commun 1991
:
1,25 ( OH ) 2-D3 is a potent regulator of
interleukin-1 induced
interleukin-8 expression and production
Hua et al., Molecular oral microbiology 2010
(Periodontal Diseases) :
Furthermore, as little as 2 µg ml(-1) mPE was sufficient to inhibit
interleukin-1ß induced secretion of
interleukin-8 in both gingival epithelial cells and THP-1 cells
Vindeløv et al., Growth Horm IGF Res 2011
(Adenoma...) :
Interleukin-8 production from human somatotroph adenoma cells is
stimulated by
interleukin-1ß and inhibited by growth hormone releasing hormone and somatostatin
Strieter et al., Am J Respir Cell Mol Biol 1990
:
The
induction of AMO derived
IL-8 by tumor necrosis factor (TNF), lipopolysaccharide (LPS), and
interleukin-1 ( IL-1 beta ) was shown to be both dose and time dependent
Mel'nichenko et al., Vopr Virusol 2011
(Herpesviridae Infections) :
There were changes in the cytokine profile,
activation of IFN-alpha, IL-2,
IL-8 , IL-10, and IL-18 gene expression, and suppression of
IL-2 gene transcription in the majority of the patients
Scholz et al., Cell Signal 1989
(Leukemia) :
Synergistic
induction of
interleukin 2 receptor ( TAC ) expression on YT cells by
interleukin 1 or tumor necrosis factor alpha in combination with cAMP inducing agents
Schultzberg et al., Neuroscience 1989
:
These antisera also inhibited
stimulation of
interleukin-2 receptor expression by purified human
interleukin-1
Falk et al., Lymphokine Res 1989
:
The cytokine
interleukin-1 plays an important role in the induction of IL-2 secretion and
IL-2 receptor expression
Lee et al., J Rheumatol 1985
(Arthritis...) :
The low
IL-2 levels was not a
result of degradation or consumption of endogenously produced
interleukin
Anastassakos et al., Clin Exp Immunol 1987
(Chronic Disease...) :
To test the hypothesis that reduced lymphocyte transformation in response to PHA in chronic hepatitis B virus infection might be due to deficient lymphokine production, lymphocyte transformation was measured in the
presence or absence of exogenous
interleukin 1,
interleukin 2 or both, or, as a source of mixed lymphokines, supernatants from mixed lymphocyte reactions
Uchiyama et al., Microbiol Immunol 1986
:
T cells obtained by the nylon wool column method alone produced
IL 2 on TSST-1 stimulation in the
presence of either macrophages or a macrophage lysate containing
interleukin 1
Mukaida et al., J Immunol 1987
(Leukemia) :
Signal requirement for
interleukin-1 dependent
interleukin 2 production by a human leukemia derived HSB.2 subclone
Soulillou et al., Eur J Cancer Clin Oncol 1985
(Hodgkin Disease) :
Peripheral blood lymphocytes ( PBL ) of patients with Hodgkin 's disease were studied for their capacity to produce
interleukin 2 upon in vitro phytohemaglutinin stimulation in the
presence or absence of either
interleukin 1 or indomethacin ( 2 micrograms/ml ) ; eight patients were studied at the discovery of their disease before receiving any therapy ( onset HD ; OHD )
Solbach et al., Blood 1984
(Sezary Syndrome) :
In this article we have studied the effects of the immunosuppressive drug cyclosporine A ( CsA ) on growth,
interleukin-2 (IL-2) production, and the
induction of
IL-2 responsiveness of peripheral blood monocytes ( PBMs ) from five patients with Sézary 's syndrome in vitro, using the lectin phytohemagglutinin ( PHA ) and the phorbol ester phorbol myristate acetate ( PMA ) as stimuli
Knop et al., Hautarzt 1984
(Dermatitis, Atopic...) :
The production of
interleukin 2 is
induced by
interleukin 1, which can be also produced by keratinocytes ( epidermal T-cell activating factor, ETAF )
Bunjes et al., Eur J Immunol 1981
:
The selective effects included a blockade of
interleukin 2 release from activated T helper cells on the one hand and
inhibition of
interleukin 1 release from splenic adherent cells on the other
Hersey et al., J Immunol 1983
(Cell Transformation, Neoplastic...) :
These supernatants did not inhibit
interleukin 1 production, and also did not
inhibit the mitogenic activity of performed
IL 2 on IL 2-dependent target cells
Okada et al., Proc Natl Acad Sci U S A 1981
:
In a clone ( 38-B ) that did not show any IL-2 activity in culture supernatants, the addition of macrophages induced IL-2 production in the presence of phytohemagglutinin, suggesting that
interleukin-1 induced
IL-2 production in T hybrid cells
Ng et al., J Biol Chem 1994
:
Although tumor necrosis factor (TNF) and
interleukin-1 ( IL ) induce the expression of the
IL-8 , TNF stimulated gene 6, and plasminogen activation inhibitor-2 genes and the activation of NF-kappa B with nearly identical kinetics, the two cytokines differ significantly in the induction of the IL-6 gene in all primary fibroblasts tested
Wei et al., J Immunol 1994
:
Induction of
IL-8 gene expression in human polymorphonuclear neutrophils by recombinant
IL-2 ... These findings suggested that the
induction of
IL-8 gene expression in PMN by
IL-2 may be involved in the recruitment of PMN into tissues during local IL-2 therapy in human cancer and in part contribute to tumor rejection
Kees et al., J Immunol Methods 1994
(Precursor Cell Lymphoblastic Leukemia-Lymphoma) :
A new human cell line for the molecular dissection of the
requirement for
interleukin-1 in the production of
interleukin-2 by immature T cells
Tilg et al., J Immunol 1993
(Carcinoma, Renal Cell...) :
TNFsRp75 had no effect on
IL-2 induced
IL-8 synthesis
Armant et al., Eur J Immunol 1996
:
Functional CD40 ligand expression on T lymphocytes in the absence of T cell receptor engagement : involvement in
interleukin-2 induced
interleukin-12 and interferon-gamma production
Van Hoffen et al., Am J Pathol 1996
:
Using immunohistochemistry,
IL-2 , IL-3, and IL-10 protein was
detected in biopsies with high rejection grades, whereas few cells expressed IL-6,
IL-8 , and IFN-gamma
Mao et al., Cell Immunol 1996
:
Cocaine down-regulates
IL-2 induced peripheral blood lymphocyte
IL-8 and IFN-gamma production ... Cocaine abrogated the
IL-2 induced production of IFN-gamma and
IL-8 in a dose-responsive manner
Jinquan et al., J Immunol 1997
(HIV Infections) :
The
IL-8R on N-B cells can be
down-regulated by IFN-gamma,
IL-2 , and TNF-alpha ( selectively on IL-8RA ), and up-regulated by IL-4 and IL-13, whereas IL-10 has no influence ... The
IL-8R on HIV-B cells can be
down-regulated by IFN-gamma and
IL-2 , and up-regulated by TNF-alpha, IL-4, and IL-10, whereas IL-13 has no influence
Elner et al., Invest Ophthalmol Vis Sci 1997
:
IL-2 did not
induce HRPE
IL-8 or MCP-1, nor did it modulate the effects of the other cytokines
Du Bois et al., J Clin Oncol 1997
(Carcinoma, Renal Cell...) :
IL-2 induced TNF bioactivity, neutrophil chemotactic defect, and serum IL-6,
IL-8 , and IL-1 receptor antagonist (IL-1RA) induction were suppressed by rhuTNFR : Fc
Bosco et al., J Immunol 1997
:
Furthermore, anti-CD14 mAbs effectively inhibited the secretion of
IL-8 and IL-1beta in
response to
IL-2
McDermott et al., Clin Cancer Res 1998
(Carcinoma, Renal Cell...) :
Whole-blood functional assays indicated that sufficient s ( CHO ) IL-1R was present in the circulation at top dose levels to inhibit the in vitro effects of IL-1beta on IL-8 induction ; however, no effect on
IL-2 induced
IL-8 induction, or on the IL-1beta- or IL-2 induced tumor necrosis factor production, was observed
Krakauer et al., J Infect Dis 1998
:
Interleukin-8 production by human monocytic cells in response to staphylococcal exotoxins is direct and
independent of
interleukin-1 and tumor necrosis factor-alpha
Aihara et al., Dig Dis Sci 1998
:
Live H. pylori
induced production of many cytokines, such as IL-1beta, IL-10,
IL-8 , IFN-gamma, and TNF-alpha, whereas we could not detect
IL-2 or IL-4