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BRAF — HIF1A
Text-mined interactions from Literome
Kumar et al., Cancer Res 2007
(Melanoma) :
Here, we report that mutant
BRAF ( V600E )
increases HIF-1alpha expression in melanoma cells ... Stable suppression of mutant
BRAF ( V600E ) or both wild-type and mutant BRAF ( V600E ) by RNA interference in melanoma cells
resulted in significantly decreased
HIF-1alpha expression ... Pharmacologic inhibition of
BRAF by BAY 43-9006 also
resulted in decreased
HIF-1alpha expression
Kikuchi et al., Cancer Res 2009
(Anoxia...) :
Many hypoxic responses are mediated by hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha, and we sought to define the
roles of mutant KRAS and
BRAF in the induction of
HIF-1alpha and HIF-2alpha in colon cancer cells ... Ectopic expression of mutant K-ras in Caco2 cells enhanced the hypoxic induction of only HIF-1alpha, whereas mutant
BRAF enhanced both
HIF-1alpha and HIF-2alpha ... Although
BRAF regulated mRNA levels of both
HIF-1alpha and HIF-2alpha, knockdown of BRAF or treatment with the MEK inhibitor PD98059 impaired the translation of only HIF-2alpha