◀ Back to IL23A

IL23A — SOCS3

Pathways - manually collected, often from reviews:

• NCI Pathway Database IL23-mediated signaling events: SOCS3 (SOCS3) → IL23/IL23R/JAK2/TYK2/SOCS3 complex (IL23A-IL12B-IL23R-IL12RB1-JAK2-TYK2-SOCS3) (modification, collaborate)
  Chen et al., Proc Natl Acad Sci U S A 2006
  Evidence: mutant phenotype, other species
• NCI Pathway Database IL23-mediated signaling events: SOCS3 (SOCS3) → IL23/IL23R/JAK2/TYK2 complex (IL23A-IL12B-IL23R-IL12RB1-JAK2-TYK2) (modification, collaborate)
  Chen et al., Proc Natl Acad Sci U S A 2006
  Evidence: mutant phenotype, other species
• NCI Pathway Database IL23-mediated signaling events: IL23/IL23R/JAK2/TYK2/SOCS3 complex (IL23A-IL12B-IL23R-IL12RB1-JAK2-TYK2-SOCS3) → IL23/IL23R/JAK2/TYK2 complex (IL23A-IL12B-IL23R-IL12RB1-JAK2-TYK2) (modification, collaborate)
  Chen et al., Proc Natl Acad Sci U S A 2006
  Evidence: mutant phenotype, other species

Text-mined interactions from Literome

Zhang et al., J Immunol 2008 (Multiple Sclerosis) : Our results demonstrated statin mediated increases in suppressor of cytokine secretion (SOCS) 3 and suppressor of cytokine secretion 7, which negatively regulate the STAT/JAK signal transduction pathway and IL-6 and IL-23 gene expression in monocytes
Ramgolam et al., J Immunol 2009 (Multiple Sclerosis) : We propose that IFN-beta-1a mediated up-regulation of the suppressor of cytokine signaling 3 expression, induced via STAT3 phosphorylation, mediates IL-1beta and IL-23 down-regulation, while IFN-beta-1a induced STAT1 phosphorylation induces IL-27p28 expression