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IL4 — NFKB1
Text-mined interactions from Literome
Takeda et al., Science 1999
(Limb Deformities, Congenital...) :
In contrast, there was no impairment of
NF-kappaB activation
induced by either
interleukin-1 or tumor necrosis factor-alpha in IKKalpha-deficient embryonic fibroblasts and thymocytes, indicating that IKKalpha is not essential for cytokine induced activation of NF-kappaB
Alaaeddine et al., Arthritis Rheum 1999
(Osteoarthritis) :
IL-4 had no effect on TNFalpha up-regulation of
NF-kappaB , and a slight decrease was noted with IL-10 and IL-13 at the highest concentration used ( 5 ng/ml )
Vig et al., J Biol Chem 1999
:
Modulation of tumor necrosis factor and
interleukin-1 dependent
NF-kappaB activity by mPLK/IRAK
Li et al., J Exp Med 1999
:
Accordingly, IKKbeta-deficient cells are defective in activation of IKK and
NF-kappaB in
response to either tumor necrosis factor alpha or
interleukin 1
Seppänen et al., Oncol Res 1998
(Adenocarcinoma...) :
In the present study, we have investigated the
effects of interferons-alpha (IFN-alpha) and -gamma ( IFN-gamma ),
interleukin-10 (IL-10) and -13 ( IL-13 ), transforming growth factor-beta1 ( TGF-beta1 ), granulocyte-macrophage colony stimulating factor ( GM-CSF ), and tumor necrosis factor-alpha (TNF-alpha) on cell proliferation and induction of transcription factors AP-1 and
NF-kappaB in UM-EC-3 human endometrial adenocarcinoma cells and UT-OC-5 ovarian carcinoma cells in vitro
Greene et al., Biochim Biophys Acta 1999
:
Interleukin-1 receptor associated kinase, IRAK, has been shown to activate
NFkappaB in
response to
interleukin-1
Belt et al., Am J Obstet Gynecol 1999
:
In this study we investigated the possible
role of the nuclear transcription factor
NF-kappaB in
interleukin-1 signaling, leading to the expression of cyclooxygenase 2 and prostaglandin production in human myometrial cell cultures ... Stimulation of human myometrial cells with
interleukin 1
leads to rapid activation of the transcription factor
NF-kappaB , which is functionally linked to the expression of cyclooxygenase 2 messenger ribonucleic acid, protein, and prostaglandin synthesis
Egan et al., J Biol Chem 1999
:
Inhibition of
interleukin-1 stimulated
NF-kappaB RelA/p65 phosphorylation by mesalamine is accompanied by decreased transcriptional activity
Sun et al., Nature 2000
:
Activation of
NF-kappaB by tumour-necrosis factor alpha and
interleukin-1 was unaffected in the mutant mice
Iber et al., Arch Biochem Biophys 2000
:
Suppression of CYP2C11 gene transcription by
interleukin-1 mediated by
NF-kappaB binding at the transcription start site
Paludan et al., Arch Virol 2000
:
IL-4 reduced virus induced TNF-alpha secretion and
nuclear factor (NF)-kappaB activation significantly, but less in cells concomitantly treated with IFN-gamma
Bendixen et al., Proc Natl Acad Sci U S A 2001
:
We show here that
IL-4 inhibits receptor activator of
NF-kappaB ligand induced osteoclast differentiation through an action on osteoclast precursors that is independent of stromal cells
Takeuchi et al., Antioxid Redox Signal 2000
:
Thioredoxin inhibits tumor necrosis factor- or
interleukin-1 induced
NF-kappaB activation at a level upstream of NF-kappaB inducing kinase
Cianferoni et al., Blood 2001
:
The inhibitory effect of ASA on
IL-4 transcription was not
mediated by decreased nuclear expression of the known salicylate target
nuclear factor (NF)-kappaB and was accompanied by reduced binding of an inducible factor to an IL-4 promoter region upstream of, but not overlapping, the NF of activated T cells- and NF-kappaB binding P1 element
Van Huffel et al., J Biol Chem 2001
:
NF-kappaB activation
induced by TNF and
interleukin-1 is inhibited by overexpression of ABIN-2
Abu-Amer et al., J Clin Invest 2001
:
It is shown here that
IL-4 reduces
NF-kappaB nuclear translocation by inhibiting IkappaB phosphorylation, thus markedly inhibiting NF-kappaB DNA binding activity and blocking osteoclastogenesis entirely ... Residual translocation of
NF-kappaB in the
presence of
IL-4 , however, suggests that nuclear mechanisms must primarily account for inhibition of NF-kappaB DNA binding and blockade of osteoclastogenesis
Fichorova et al., J Infect Dis 2001
(HIV Infections...) :
Analysis of molecular and cellular components in cervicovaginal secretions, as well as results from in vitro activation of cervicovaginal epithelial cells and U1/HIV promonocytic cells, showed that multiple N-9 use can promote HIV-1 transmission through
interleukin-1 mediated
NF-kappaB activation, which leads to chemokine induced recruitment of HIV-1 host cells and increased HIV-1 replication in infected cells
Qian et al., J Biol Chem 2001
:
IRAK mediated translocation of TRAF6 and TAB2 in the
interleukin-1 induced activation of
NFkappa B
Bradbury et al., Cancer Res 2001
:
Recently, it also has been demonstrated that nonsteroidal anti-inflammatory agents inhibit tumor necrosis factor and
interleukin-1 induced
NF-kappaB activation and act as radiosensitizing agents
Zamorano et al., Int Immunol 2001
:
IL-4 enhanced TNF-alpha induced activation of the transcription factor
NF-kappaB ... Supporting this hypothesis,
IL-4 also
increased NF-kappaB activation induced by anti-CD3 antibodies in primary T cells and protected them from apoptosis induced by receptor engagement
Wei et al., J Biol Chem 2002
(MAP Kinase Signaling System) :
Consistent with this observation, the inhibitory
effects of
IL-4 on RANKL induced
NF-kappa B and mitogen activated protein kinase activation are STAT6 dependent
Beppu et al., Biochim Biophys Acta 2002
(Carcinoma, Squamous Cell...) :
Regarding their mechanisms to inhibit the expression of MMP-9 and uPA, DEX and
IL-4 had no effect on the cell surface levels of TNFalpha receptors, but
inhibited the activation of
NF-kappaB and NF-kappaB dependent gene expression
Wright et al., Am J Physiol Heart Circ Physiol 2002
:
However,
interleukin-1beta and phorbol 12-myristate 13-acetate also
activated NF-kappaB but did not evoke TNF-alpha expression, revealing that this factor is not sufficient for cytokine production
Palanki et al., Curr Med Chem 2002
(Autoimmune Diseases) :
In activated T cells, transcription factors such as the activator protein-1 (AP-1) regulate IL-2 production and production of matrix metalloproteinases, the
nuclear factor kappa B (NF-kappa B) is essential for the transcriptional regulation of the proinflammatory cytokines IL-1, IL-6, IL-8 and TNF alpha, and nuclear factor of activated T-cells ( NFAT ) is
required for the transcriptional regulation of IL-2, IL-3,
IL-4 , IL-5, IL-8, IL-13, TNF alpha, and GM-CSF
Goletti et al., Cytokine 2002
:
IL-4 inhibited LTR-driven transcription triggered by PMA stimulation of U1 cells, and this effect was
dependent upon intact
NF-kappaB but not Sp-1 binding sites
Friedman et al., J Virol 2002
:
We demonstrate here that the E3 region of Ad inhibits the activation of
NF-kappa B induced by tumor necrosis factor alpha (TNF-alpha) and
interleukin-1
Liacini et al., Matrix Biol 2002
(Osteoarthritis, Hip) :
Inhibition of
interleukin-1 stimulated MAP kinases, activating protein-1 (AP-1) and
nuclear factor kappa B (NF-kappa B) transcription factors down-regulates matrix metalloproteinase gene expression in articular chondrocytes
Raychaudhuri et al., Clin Immunol 2002
(Hypertension, Pulmonary) :
However, mRNA expression was decreased compared to controls for
NF-kappaB regulated genes, granulocyte macrophage colony stimulating factor,
interleukin-6 , macrophage inflammatory protein-1alpha ( MIP-1alpha ), and vascular endothelial growth factor
Cogswell et al., J Biol Chem 2003
:
Stimulation of cells with inflammatory cytokines such as tumor necrosis factor alpha or
interleukin-1 induces the degradation of I kappa B, the
inhibitor of
NF-kappa B , allowing nuclear accumulation of NF-kappa B and regulation of specific gene expression
Kim et al., Mol Cells 2003
:
IGF-1 increased the activity of signal transducer and activator of transcription 6 ( STAT6 ) in
response to
IL-4 , and activated
NF-(kappa)B
Zamorano et al., J Immunol 2003
:
We previously found that
IL-4 and TNF-alpha cooperate in the
activation of STAT6 and
NF-kappaB , suggesting that these transcription factors are regulated by common intracellular signaling pathways
Jiang et al., J Biol Chem 2004
:
Without ERK activation,
interleukin-1beta induces only acute and transient
NF-kappaB activation
Ackermann et al., Immunology 2004
:
In studies using human intestinal epithelial cells ( HT29 ), multiple inhibitors of the transcription factor nuclear factor-kappaB
(NF-kappaB) , including a dominant negative IkappaBalpha-serine mutant,
inhibited both
IL-4- and IFN dependent increases in pIgR expression ... Finally, reporter gene studies with NF-kappaB enhancer elements indicated that IFN-gamma alone and
IL-4 in combination with other cytokines
activated NF-kappaB in HT29 cells
Yamamoto et al., Biochem Biophys Res Commun 2004
(Inflammation) :
Involvement of
NF-kappaB in TGF-beta mediated suppression of
IL-4 signaling
Takada et al., J Biol Chem 2004
:
PTD-p65-P1 suppressed
NF-kappaB activation
induced by lipopolysaccharide,
interleukin-1 , okadaic acid, phorbol 12-myristate 13-acetate, H ( 2 ) O ( 2 ), and cigarette smoke condensate as well as that induced by TNF
Dedeoglu et al., Int Immunol 2004
:
IL-4 induced STAT6 binding to a site in the 5 ' upstream region of the AID gene, while CD40 ligation induced
NFkappaB binding to two sites in that region
Li-Weber et al., Eur J Immunol 2004
:
In this study, we show that the
IL-4 promoter is synergistically
activated by
NF-kappa B , NF-AT and NF-IL6 at the NF-kappa B/NF-AT/NF-IL6 composite sites ... Inhibition of
NF-kappa B nuclear translocation in living cells
blocked binding of NF-kappa B to the
IL-4 promoter ... The data provide first evidence that
NF-kappa B is directly
involved in
IL-4 transcription
Lgssiar et al., Experimental biology and medicine (Maywood, N.J.) 2004
(Diabetes Mellitus, Experimental) :
Interleukin-11 prevented diabetes without affecting insulitis ; attenuated TNF-alpha and IFN-gamma response ; and stimulated
IL-4 production and
inhibited activation of IKK-alpha,
NF-kappaB , and AP-1
Xu et al., World J Gastroenterol 2004
:
NF-kappaB decoy ODNs completely abrogated
IL-4 induced DC maturation and allocostimulatory activity as well as LPS induced
NF-kappaB activation and IL-12 protein expression in DCs
Shishodia et al., J Biol Chem 2004
(Inflammation...) :
Guggulsterone suppressed DNA binding of
NF-kappaB induced by tumor necrosis factor (TNF), phorbol ester, okadaic acid, cigarette smoke condensate, hydrogen peroxide, and
interleukin-1
Kwon et al., Mol Cell Biol 2004
:
Signaling molecule that interacts with mouse pelle-like kinase ( SIMPL ) is a signaling component required for tumor necrosis factor alpha (TNF-alpha) dependent but not
interleukin-1 dependent
NF-kappaB activation
Jain et al., J Clin Invest 2004
(Ectodermal Dysplasia...) :
This suggests that these NF-kappaB components have different activation requirements and that
IL-4 can
augment some but not all NEMO dependent
NF-kappaB signaling
Lee et al., Prostate 2005
(Prostatic Neoplasms) :
IL-4 increases
NF-(kappa)B transcriptional activity in prostate cancer cells which can be blocked by the addition of IL-4 antibody ...
IL-4 can also rapidly
activate NF-kappaB ... Furthermore, the
IL-4 induced
NF-kappaB activation and nuclear translocation can be blocked by LY294002, a PI3K/Akt specific inhibitor, suggesting that IL-4 induced NF-(kappa)B activation is mediated by activation of PI3K/Akt pathway
Feng et al., Mol Cell Biol 2005
:
The LIM protein Ajuba influences
interleukin-1 induced
NF-kappaB activation by affecting the assembly and activity of the protein kinase Czeta/p62/TRAF6 signaling complex
Park et al., Biochemistry 2005
:
Inhibition of
NF-kappaB by cobrotoxin
resulted in reductions in the LPS induced expressions of COX-2, iNOS, cPLA(2),
IL-4 , and TNF-alpha in astrocytes and in COX-2 expression induced by SNP, LPS, and TNF-alpha in astrocytes
Mangashetti et al., J Immunol 2005
(Bone Resorption...) :
Thus, we reveal that
IL-4 acts directly on mature osteoclasts and inhibits bone resorption by
inhibiting NF-kappaB and Ca ( 2+ ) signaling
Wang et al., Nat Immunol 2006
:
Tumor necrosis factor receptor associated factor 6 ( TRAF6 ) is critical for mediating Toll-like receptor ( TLR )
-interleukin 1 receptor (IL-1R) signaling and subsequent
activation of
NF-kappaB and AP-1, transcriptional activators of innate immunity
Paintlia et al., J Immunol 2006
(Demyelinating Diseases...) :
IL-4 induced peroxisome proliferator activated receptor gamma activation
inhibits NF-kappaB trans activation in central nervous system ( CNS ) glial cells and protects oligodendrocyte progenitors under neuroinflammatory disease conditions : implication for CNS demyelinating diseases
LaVallie et al., J Biol Chem 2006
(Osteoarthritis) :
Protein kinase Czeta is up-regulated in osteoarthritic cartilage and is required for
activation of
NF-kappaB by tumor necrosis factor and
interleukin-1 in articular chondrocytes
Jang et al., Cell Immunol 2006
:
In fact,
IL-4 induced specific activation of
NF-kappaB , Akt, and Erk in Jurkat T cells and partially rescued these cells from dexamethasone induced apoptosis
Komine et al., Mol Immunol 2007
(Periodontitis) :
Con A low-affinity saliva Lf peptides, PR3 treated Lf preparation and two of four synthetic polypeptides induced the production of
interleukin IL-6, monocyte chemoattractant protein-1 and IL-8, and the
activation of
NF-kappaB in human oral epithelial HSC-2 cells
Suzuki et al., Trends Immunol 2006
:
Although each system seems to possess distinct activation mechanisms,
interleukin-1 receptor associated kinase ( IRAK)-4 is
essential for
NF-kappaB activation in Toll-like receptor ( TLR ) and T-cell receptor ( TCR ) signaling pathways
Frasca et al., Exp Gerontol 2007
:
Therefore,
NF-kappaB is not involved in the decreased
response of old B cells to
anti-CD40/IL-4
Wullaert et al., J Biol Chem 2007
:
Similar to the other ABINs, ABIN-3 binds to A20 and inhibits
NF-kappaB activation
induced by tumor necrosis factor,
interleukin-1 , and 12-O-tetradecanoylphorbol-13-acetate
Ahn et al., J Biol Chem 2007
:
Besides TNF, gamma-tocotrienol also abolished
NF-kappaB activation
induced by phorbol myristate acetate, okadaic acid, lipopolysaccharide, cigarette smoke,
interleukin-1beta , and epidermal growth factor
Hohmann et al., J Biol Chem 1992
(Leukemia, Promyelocytic, Acute) :
NF-kappa B activation by phorbol 12-myristate 13-acetate ( PMA ) and
interleukin-1 was inhibited by staurosporin
Manna et al., Clin Cancer Res 2007
(Inflammation...) :
We showed by DNA binding assay that
NF-kappaB activation
induced by tumor necrosis factor (TNF), phorbol 12-myristate 13-acetate, lipopolysaccharide, ceramide,
interleukin-1 , and H ( 2 ) O ( 2 ) was suppressed by morin ; the suppression was not cell type specific
Thieu et al., J Leukoc Biol 2007
:
IL-4 stimulated
NF-kappaB activity is required for Stat6 DNA binding ...
IL-4 induced
NF-kappaB p52 production requires PI-3K activity and correlates with IkappaB kinase phosphorylation and TNF receptor associated factor 3 degradation
Krasnow et al., Cytokine 1991
(Lymphoma, T-Cell) :
Tumor necrosis factor-alpha,
interleukin 1, and phorbol myristate acetate are independent
activators of
NF-kappa B which differentially activate T cells
Liu et al., J Immunol 2007
:
Activation of
NF-kappaB , STAT6, and STAT1 was
induced in eosinophils by TNF-alpha,
IL-4 , and IFN-gamma, respectively
Shembade et al., J Virol 2007
:
Mouse fibroblasts lacking Ubc13 exhibit impaired Tax activation of NF-kappaB despite normal tumor necrosis factor- and
interleukin-1 mediated
NF-kappaB activation
Voboril et al., Neoplasma 2007
(Colorectal Neoplasms) :
IL-4 or IL-10 ( 1, 10, 100 ng/ml ) neither inhibited growth and clonogenicity nor
activated NF-kappaB , but they sensitized cells to irradiation in a dose dependent manner
Dey et al., Cell Death Differ 2008
:
We show in this study that R-Roscovitine can downregulate
nuclear factor-kappa B (NF-kappaB) activation in
response to tumor necrosis factor (TNF)alpha and
interleukin 1
Kim et al., Mol Pharmacol 2008
(Inflammation...) :
BOT-64 attenuates
NF-kappaB regulated expression of inflammatory genes such as inducible nitric-oxide synthase, cyclooxygenase-2, tumor necrosis factor-alpha,
interleukin (IL)-1beta , and IL-6 in LPS activated or expression vector IKKbeta transfected macrophages
Park et al., J Microbiol Biotechnol 2008
(Hypersensitivity, Immediate) :
These extracts also inhibited mRNA expression of TNF-alpha and
IL-4 , as well as
NF-kappaB activation in RBL-2H3 cells induced by the IgE-antigen complex
Xiao et al., J Biol Chem 2008
:
Pellino 3b negatively regulates
interleukin-1 induced TAK1 dependent
NF kappaB activation
Dasu et al., Diabetes 2008
:
High glucose increased TLR expression, myeloid differentiation factor 88,
interleukin-1 receptor associated kinase-1, and
nuclear factor-kappaB (NF-kappaB) p65 dependent
activation in THP-1 cells
Wijagkanalan et al., Mol Pharmacol 2008
(Pneumonia) :
DPML significantly inhibited tumor necrosis factor alpha,
interleukin-1beta , and cytokine induced neutrophil chemoattractant-1 levels, suppressed neutrophil infiltration and myeloperoxidase activity, and
inhibited NFkappaB and p38 mitogen activated protein kinase activation in the lung
Inagaki et al., J Biol Chem 2008
:
Tumor necrosis factor- and
interleukin-1 induced activation of TAK1 was entirely normal in Tab1-deficient MEFs and could
activate both mitogen activated protein kinases and
NF-kappaB
Gao et al., Cell Mol Life Sci 2009
:
Transforming growth factor-beta activated kinase 1 ( TAK1 ) is a serine/threonine protein kinase that is critically involved in the
activation of
NF-kappaB by tumor necrosis factor ( TNFalpha ),
interleukin-1beta (IL-1beta) and TLR ligands
de Mejia et al., Peptides 2009
(Inflammation) :
The 5 kDa peptide inhibited most potently pro-inflammatory markers including interleukin-6 production ( IC ( 50 ) =2 microM ),
interleukin-1beta production ( IC ( 50 ) =13 microM ),
nuclear factor-kappa B (NF-kappaB) transactivation ( IC ( 50 ) =21 microM ), cyclooxygenase-2 expression ( IC ( 50 ) =25 microM ), nitric oxide production ( IC ( 50 ) =28 microM ), inducible nitric oxide synthase expression ( IC ( 50 ) =37 microM ), prostaglandin E ( 2 ) production ( IC ( 50 ) =41 microM ), p65 nuclear translocation ( IC ( 50 ) =48 microM ) and p50 nuclear translocation ( IC ( 50 ) =77 microM )
Lohoff et al., J Biol Chem 2010
:
We also show that Egr-1, nuclear factor of activated T cell, and
NF-kappaB cooperatively bind to an NFAT/NF-kappaB overlapping IL-4 enhancer element and
activate the
IL-4 promoter synergistically
Sheller et al., Exp Lung Res 2009
(Asthma...) :
Accompanying the exaggerated inflammation was an increase in the cytokines granulocyte colony stimulating factor ( G-CSF ), interleukin (IL)-15, and KC. Interestingly, the counter regulatory
interleukin , IL-10, was
suppressed by
NF-kappa B activation
Yao et al., Inflamm Res 2010
:
Moreover,
NF-kappaB p50, COX-2, and iNOS levels in SF were markedly
suppressed by
AD-IL-18BP/IL-4 ...
AD-IL-18BP/IL-4 can
suppress the production and expression of inflammatory cytokines such as COX-2, iNOS, and
NF-kappaB in LPS stimulated SF
Trinh et al., Arch Pharm Res 2009
(Pruritus) :
These curcuminoids also inhibited degranulation, protein expression of TNF-alpha and
IL-4 , and transcription factor
NF-kappaB activation in IAC induced RBL-2H3 cells
Munitz et al., Gastroenterology 2010
(Colitis...) :
In vitro analysis showed increased production of proinflammatory cytokines ( interleukin-6,
interleukin-1beta , and tumor necrosis factor alpha ) and
activation of MAPK and
NF-kappaB in Pirb-/- macrophages following bacterial activation
Schreck et al., EMBO J 1991
:
NAC and other thiol compounds also blocked the
activation of
NF-kappa B by cycloheximide, double stranded RNA, calcium ionophore, TNF-alpha, active phorbol ester,
interleukin-1 , lipopolysaccharide and lectin
Mahon et al., J Biol Chem 1995
(Lymphoma, T-Cell...) :
The tyrosine kinase inhibitor herbimycin A was found to block
NF-kappa B stimulation in
response to
interleukin-1 and phorbol 12-myristate 13-acetate in EL4.NOB-1 thymoma cells and phorbol 12-myristate 13-acetate in Jurkat T lymphoma cells
Lewis et al., Mol Cell Biol 1994
:
Mutational analysis of the -127/-118 NF-kappa B site indicates that both
NF-kappa B and HMG-I(Y) binding at this site are
essential for
interleukin-1 induction of the promoter
Clarke et al., Eur J Immunol 1995
:
Interleukin-4 inhibits kappa light chain expression and
NF kappa B activation but not I kappa B alpha degradation in 70Z/3 murine pre-B cells ... We investigated whether
IL-4 could
inhibit the up-regulation of kappa light chain and activation of
NF kappa B by LPS in 70Z/3 ...
IL-4 was also found partially to
inhibit NF kappa B activity induced by tumor necrosis factor-alpha (TNF-alpha) and interleukin-1-beta (IL-1 beta)
Scheinman et al., Mol Cell Biol 1995
:
In HeLa cells, DEX activation of endogenous GR is sufficient to block tumor necrosis factor alpha or
interleukin 1
activation of
NF-kappa B at the levels of both DNA binding and transcriptional activation
Ng et al., J Biol Chem 1994
:
Although tumor necrosis factor (TNF) and
interleukin-1 ( IL ) induce the expression of the IL-8, TNF stimulated gene 6, and plasminogen activation inhibitor-2 genes and the activation of
NF-kappa B with nearly identical kinetics, the two cytokines differ significantly in the induction of the IL-6 gene in all primary fibroblasts tested
Dokter et al., Leukemia 1996
:
Neither IL-10 nor
IL-4 inhibited LPS induced
NF-kappa B binding activity
Takeshita et al., J Immunol 1996
:
Electrophoretic mobility shift assays showed that
IL-4 , but not IL-10,
inhibited nuclear
NF-kappaB activity, and that IL-4 and IL-10 did not affect NF-IL-6 activity
Yanagihara et al., J Allergy Clin Immunol 1996
:
These results indicate that
NF-kappa B activity is commonly
inducible in DND39 cells by
IL-4 and anti-CD40 mAb and suggest that NF-kappa B sensitive to NAC may play a role in regulating IgE synthesis in B cells
Pindolia et al., Hematopathol Mol Hematol 1996
:
Furthermore, while unable to induce the activation of NF-kB alone,
IL-4 enhanced the activation of
NF-kB by IL-1
De Valck et al., Biochem Biophys Res Commun 1997
:
However, A20 mutants that no longer associated with 14-3-3 proteins could still fully inhibit
NF-kappaB activation
induced by tumor necrosis factor,
interleukin-1beta or phorbol 12-myristate 13-acetate, thus excluding a crucial role for 14-3-3 interaction in this A20 function
Bowie et al., J Biol Chem 1997
:
Here we have investigated the effect of a range of putative antioxidants on
NF-kappaB activation by
interleukin-1 and tumor necrosis factor as well as the ability of H2O2 to activate NF-kappaB in primary human umbilical vein endothelial cells and the transformed human endothelial cell line ECV304
Chaturvedi et al., J Biol Chem 1997
:
As sanguinarine also inhibited
NF-kappaB activation
induced by
interleukin-1 , phorbol ester, and okadaic acid but not that activated by hydrogen peroxide or ceramide, the pathway leading to NF-kappaB activation is likely different for different inducers
Gri et al., J Biol Chem 1998
(Cell Transformation, Viral) :
Synergistic
regulation of the human
interleukin-12 p40 promoter by
NFkappaB and Ets transcription factors in Epstein-Barr virus transformed B cells and macrophages
Giri et al., J Biol Chem 1998
(Lymphoma, T-Cell...) :
HuT-78 cells were also resistant to
NF-kappaB activation
induced by phorbol ester, H2O2, ceramide, endotoxin, and
interleukin-1
Clarke et al., Eur J Immunol 1998
:
Therefore we conclude that although IL-10 or
IL-4 can
suppress NF kappa B activity, this appears to have little effect on the expression of the TNF-alpha gene and is unlikely to be the basis of the anti-inflammatory effects of these cytokines
Heitmeier et al., J Biol Chem 1998
:
Double stranded RNA induced inducible nitric-oxide synthase expression and
interleukin-1 release by murine macrophages
requires NF-kappaB activation
Nakazato et al., Kidney Int 1998
:
In contrast,
IL-4 did not
affect basal and IL-1 induced
NF-kappa B activities
Schwager et al., Vet Immunol Immunopathol 1998
(Ascorbic Acid Deficiency...) :
The results suggest that ascorbate levels exert an early effect on immune homeostasis via reactive oxygen intermediates ( ROI ) -dependent expression of interleukin genes, since the transcription factor
NF-kappa B is sensitive to ROI and
regulates the expression of
interleukin genes
Jeppson et al., J Immunol 1998
:
These data indicate that both
IL-4 and anti-CD40 are
required to induce
NF-kappa B activation and IL-6 transcription and production, and implicate these events in a signaling pathway augmenting IgE production in human B lymphocytes
Béraud et al., Proc Natl Acad Sci U S A 1999
:
The compound had virtually no effect on tumor necrosis factor- and
interleukin-1 induced
NF-kappaB activities