Saura et al., J Neurochem 2003
:
Two NF-kappa B inhibitors, aspirin ( 10 mM ) and MG-132 ( 0.1 microM ), blocked basal apoE and apoJ secretion as well as LPS induced apoJ secretion
Du et al., Brain Res Mol Brain Res 2005
:
NF-(kappa)B mediates amyloid beta peptide stimulated activity of the human apolipoprotein E gene promoter in human astroglial cells ... We examined how A ( beta ) treatment affects APOE expression in cultured cells and tested the role of the transcription factor NF-(kappa)B in APOE gene regulation ... Our data provide evidence that upregulation of APOE by A ( beta ) in astroglial cells is mediated by an NF-(kappa)B-element present in the 5'-flanking region of the APOE gene
Maezawa et al., Journal of neuroinflammation 2006
:
Our results suggest that LPS activation of innate immune response in TR APOE glia results in opposing outcomes from microglia and astrocytes as a result of TR APOE dependent activation of p38MAPK or NF-kappaB signaling in these two cell types
Kawamura et al., Arterioscler Thromb Vasc Biol 2007
(Atherosclerosis) :
Studies in VSMCs overexpressing IL-1beta signaling intermediates revealed that NF-kappaB transactivation was inhibited by apoE in MyD88- and IRAK1- but not in TRAF6 transfected cells