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APP — MAPK8
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
MAPK8
—
APP
(direct interaction, pull down)
Oláh et al., J Biol Chem 2011
-
IRef Biogrid Interaction:
MAPK8
—
APP
(direct interaction, enzymatic study)
Scheinfeld et al., J Biol Chem 2003*
-
IRef Biogrid Interaction:
MAPK8
—
APP
(direct interaction, pull down)
Scheinfeld et al., J Biol Chem 2003*
-
IRef Innatedb Interaction:
Complex of APP-MAPK8IP1-MAPK8
(unknown, -)
Scheinfeld et al., J Biol Chem 2003*
-
IRef Innatedb Interaction:
MAPK8
—
APP
(unknown, -)
Scheinfeld et al., J Biol Chem 2003*
Text-mined interactions from Literome
Rossner et al., Neurosci Lett 1999
:
Our data demonstrate, that activation of
mitogen activated protein ( MAP ) kinase alone is
sufficient to promote
APP secretion, whereas inhibition of MAP kinase will reduce APP secretion only when phospholipase Cgamma or phosphatidylinositol 3-kinase are additionally inhibited
Lee et al., Mol Med 2001
(Mammary Neoplasms, Experimental) :
Ad1-536 or AdL540Q infection inhibited T47D cell growth and induced apoptosis,
increasing Bax protein and phosphorylation of p38
mitogen-activated-protein kinase ( MAPK )
Ruiz-León et al., J Neurochem 2004
(Neuroblastoma) :
Taken together, our results suggest that simultaneous activation of at least two signalling pathways,
Ras/MAPK and PI3K/Akt, is
necessary to mediate a full activation of the
APP promoter by BDNF
Westra et al., Ann Rheum Dis 2006
(Carcinoma, Hepatocellular...) :
The
effects of p38
MAPK inhibition on
APP production and mRNA expression in four human hepatoma cell lines was investigated, after stimulation with interleukin (IL)6 and/or IL1beta or tumour necrosis factor alpha