Gene interactions and pathways from curated databases and text-mining

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NR4A2 — TNF

Text-mined interactions from Literome

McEvoy et al., J Immunol 2002 (Arthritis, Rheumatoid) : We have established that transcriptional activation of the NURR1 gene by IL-1beta and TNF-alpha requires a proximal promoter region that contains a consensus NF-kappaB DNA binding motif
Liu et al., Biochem Biophys Res Commun 2005 : RG and PG attenuated TNFalpha mediated induction of trans acting factor ( s ) Nur77/Nurr1 and binding of nuclear proteins ( NP ) to the cis acting element ( NBRE )
O'Kane et al., J Invest Dermatol 2008 (Psoriasis) : Increased expression of the orphan nuclear receptor NURR1 in psoriasis and modulation following TNF-alpha inhibition
Aherne et al., Mol Immunol 2009 (Arthritis) : Transcriptional effects of NR4A2 on the human IL-8 promoter are enhanced in the presence of TNF-alpha , suggesting molecular crosstalk between TNF-alpha signalling and NR4A2