◀ Back to PARP1
PARP1 — PRKDC
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
PARP1
—
PRKDC
(physical association, affinity chromatography technology)
Ju et al., Science 2006*
-
MIPS CORUM NCOA6-DNA-PK-Ku-PARP1 complex:
NCOA6-DNA-PK-Ku-PARP1 complex complex (NCOA6-PARP1-PRKDC-XRCC5-XRCC6)
Ko et al., J Biol Chem 2003
-
IRef Corum Interaction:
Complex of NCOA6-PRKDC-XRCC5-XRCC6-PARP1
(association, pull down)
Ko et al., J Biol Chem 2003
-
IRef Dip Interaction:
Complex of 21 proteins
(tandem affinity purification)
Shuaib et al., Proc Natl Acad Sci U S A 2010
-
IRef Hprd Interaction:
Complex of 51 proteins
(in vivo)
Rubin et al., Cancer Res 2007*
-
IRef Hprd Interaction:
Complex of 65 proteins
Wong et al., Cell 2009
-
IRef Hprd Interaction:
Complex of 2739 proteins
(in vivo)
Czubaty et al., Biochim Biophys Acta 2005
-
IRef Hprd Interaction:
Complex of 50 proteins
(in vivo)
Mayeur et al., J Biol Chem 2005
-
IRef Hprd Interaction:
PARP1
—
PRKDC
(in vivo)
Morrison et al., Nat Genet 1997*
-
IRef Hprd Interaction:
Complex of 37 proteins
(in vivo)
Ko et al., J Biol Chem 2003
-
IRef Intact Interaction:
Complex of 12 proteins
(association, pull down)
Kanno et al., EMBO J 2007
-
IRef Intact Interaction:
Complex of PARP1-ETS1-XRCC5-PRKDC-XRCC6
(association, anti tag coimmunoprecipitation)
Brenner et al., Cancer Cell 2011
-
IRef Intact Interaction:
Complex of XRCC6-PARP1-XRCC5-PRKDC-ETV1
(association, anti tag coimmunoprecipitation)
Brenner et al., Cancer Cell 2011
-
IRef Intact Interaction:
Complex of XRCC5-ERG-XRCC6-PARP1-PRKDC
(association, anti tag coimmunoprecipitation)
Brenner et al., Cancer Cell 2011
-
IRef Intact Interaction:
Complex of 46 proteins
(association, anti tag coimmunoprecipitation)
Abramson et al., Cell 2010
-
IRef Intact Interaction:
Complex of 117 proteins
(association, tandem affinity purification)
Zhao et al., Journal of proteomics 2011
-
IRef Intact Interaction:
Complex of 28 proteins
(association, pull down)
Czubaty et al., Biochim Biophys Acta 2005
-
IRef Intact Interaction:
Complex of 23 proteins
(association, anti bait coimmunoprecipitation)
Czubaty et al., Biochim Biophys Acta 2005
-
IRef Intact Interaction:
Complex of PRKDC-DDX5-SSRP1-PARP1-HDAC1-HDGF-SRSF1
(association, pull down)
Zhao et al., Journal of proteomics 2011
-
IRef Intact Interaction:
Complex of 60 proteins
(association, tandem affinity purification)
Zhao et al., Journal of proteomics 2011
-
IRef Intact Interaction:
Complex of 306 proteins
(association, pull down)
Komarova et al., Mol Cell Proteomics 2011
-
IRef Intact Interaction:
Complex of 248 proteins
(association, pull down)
von Eyss et al., EMBO J 2012
-
IRef Intact Interaction:
Complex of 11 proteins
(association, anti tag coimmunoprecipitation)
Wong et al., Cell 2009
-
IRef Intact Interaction:
Complex of PRKDC-XRCC5-XRCC6-PARP1-XRCC6-PARP1-XRCC5-PRKDC
(association, anti bait coimmunoprecipitation)
Brenner et al., Cancer Cell 2011
-
IRef Intact Interaction:
Complex of XRCC6-PRKDC-XRCC5-PARP1-ERG
(association, anti bait coimmunoprecipitation)
Brenner et al., Cancer Cell 2011
-
IRef Intact Interaction:
Complex of 16 proteins
(association, anti tag coimmunoprecipitation)
Abramson et al., Cell 2010
-
IRef Intact Interaction:
Complex of XRCC6-PARP1-PRKDC
(association, anti bait coimmunoprecipitation)
Brenner et al., Cancer Cell 2011
-
IRef Intact Interaction:
Complex of PARP1-PRKDC-XRCC5-XRCC6-SPI1
(association, anti tag coimmunoprecipitation)
Brenner et al., Cancer Cell 2011
-
IRef Intact Interaction:
Complex of TOP2B-PRKDC-USF1-KAT2B-PARP1-XRCC5
(physical association, anti bait coimmunoprecipitation)
Wong et al., Cell 2009
-
IRef Intact Interaction:
Complex of PARP1-PRKDC-TOP2A-XRCC5
(association, anti bait coimmunoprecipitation)
Abramson et al., Cell 2010
-
IRef Intact Interaction:
Complex of PRKDC-ERG-PARP1-ERG-PRKDC-PARP1
(association, anti bait coimmunoprecipitation)
Brenner et al., Cancer Cell 2011
-
IRef Intact Interaction:
Complex of H2AFX-XRCC5-TOP2A-AIRE-PARP1-PRKDC
(association, anti bait coimmunoprecipitation)
Abramson et al., Cell 2010
-
IRef Intact Interaction:
Complex of 21 proteins
(physical association, anti tag coimmunoprecipitation)
Behrends et al., Nature 2010
-
IRef Intact Interaction:
Complex of TOP2B-HDAC9-PRKDC-XRCC5-USF1-PARP1-XRCC6-KAT2B-USF2
(association, anti bait coimmunoprecipitation)
Wong et al., Cell 2009
-
IRef Intact Interaction:
Complex of ERG-PARP1-PRKDC-XRCC5
(association, anti bait coimmunoprecipitation)
Brenner et al., Cancer Cell 2011
-
IRef Ophid Interaction:
PARP1
—
PRKDC
(aggregation, confirmational text mining)
Morrison et al., Nat Genet 1997*
-
IRef Ophid Interaction:
PARP1
—
PRKDC
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Ariumi et al., Oncogene 1999
:
Thus,
DNA-PK suppresses
PARP activity, probably through direct binding and/or sequestration of DNA-ends which serve as an important stimulator for both enzymes
Veuger et al., Oncogene 2004
:
Inactive
DNA-PK suppressed the activity of
PARP-1 and vice versa ... The inhibitory
effect of
DNA-PK on
PARP activity was confirmed in permeabilized cells
Dregalla et al., Aging 2010
(Chromosomal Instability...) :
We provide the first evidence for
regulation of
DNA-PKcs by tankyrase 1
PARP activity and taken together, identify roles of tankyrase 1 with implications not only for DNA repair and telomere biology, but also for cancer and aging
Calkins et al., Nucleic Acids Res 2013
:
Loss of DNA-PK function prevented activation of PARP-1 and its recruitment to chromatin in damaged cells, suggesting
regulation of
PARP-1 by
DNA-PK within a pathway of DNA repair
Ruscetti et al., J Biol Chem 1998
:
The protein kinase activity of
DNA-PK can be
stimulated by
PARP in the presence of NAD+ in a reaction that is blocked by the PARP inhibitor 1, 5-dihydroxyisoquinoline