Smith et al., Proc Natl Acad Sci U S A 2008
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We also demonstrate that exogenous expression of Bves reduces Rac1 and Cdc42 activity levels while not affecting levels of active RhoA Russ et al., Invest Ophthalmol Vis Sci 2010
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Given that Bves has been reported in multiple ocular tissues, the authors hypothesize that Bves plays a role in the regulation of RhoA signaling in trabecular meshwork ( TM ) cells ... Increased Bves in TM cells leads to increased TJ formation with decreased RhoA activation and decreased MLC-p
Russ et al., PloS one 2011
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These studies demonstrate that Bves expression and localization can regulate RhoA and ZONAB/DbpA activity