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IKBKB — IL6

Text-mined interactions from Literome

Li et al., J Exp Med 1999 : Accordingly, IKKbeta-deficient cells are defective in activation of IKK and NF-kappaB in response to either tumor necrosis factor alpha or interleukin 1
Jeong et al., Cell Signal 2002 (Calcium Signaling) : These observations demonstrate that the intracellular Ca2+ may play an important role in IgE induced TNF-alpha and IL-6 secretion from mast cells via IKKbeta activation
Andreakos et al., Blood 2004 : In contrast, in macrophages neither MyD88, Mal/TIRAP, nor I kappa B kinase 2 (IKK2) are required for NF-kappa B activation or tumor necrosis factor alpha (TNF alpha), IL-6 , or IL-8 production, although Mal/TIRAP is still involved in the production of interferon beta (IFN beta)
Podolin et al., J Pharmacol Exp Ther 2005 (Arthritis, Experimental...) : In the present study, we demonstrate that a novel, potent ( IC ( 50 ) = 17.9 nM ), and selective inhibitor of human IKK-2 , 2- [ ( aminocarbonyl ) amino ] -5- ( 4-fluorophenyl ) -3-thiophenecarboxamide ( TPCA-1 ), inhibits lipopolysaccharide induced human monocyte production of TNF-alpha, IL-6 , and IL-8 with an IC ( 50 ) = 170 to 320 nM
Zhang et al., EMBO Rep 2005 : Using IKK(beta)-deficient bone-marrow derived macrophages and mouse embryo fibroblasts ( MEFs ), we show that IKK(beta) is essential for IKK and NF-(kappa)B activation as well as efficient IL-6 induction
Catley et al., Mol Pharmacol 2006 (Pulmonary Disease, Chronic Obstructive) : As observed above, ICAM-1, IL-6 , IL-8, GM-CSF, RANTES, MCP-1, GROalpha, NAP-2, and ENA-78 expression was reduced by the IKK inhibitors
Chen et al., J Immunol 2006 : Peptidoglycan induced IL-6 production in RAW 264.7 macrophages is mediated by cyclooxygenase-2, PGE2/PGE4 receptors, protein kinase A, I kappa B kinase , and NF-kappa B
Lamothe et al., J Biol Chem 2007 : Reconstituting TRAF6-deficent cells with various TRAF6 mutants, we clearly demonstrate the requirement for the TRAF6 RING domain and site-specific auto-ubiquitination of TRAF6 to activate IKK in response to interleukin-1
Grund et al., Mol Pharmacol 2008 (Endometriosis...) : Interestingly, MEK, p38, and IKK inhibitors block TNF-alpha induced IL-8, IL-6 , and GM-CSF secretion and 12z invasion, whereas the PI3K inhibitors do not
Shah et al., PloS one 2011 : Furthermore, this study showed that the NF-?B pathway is involved in gp120 mediated IL-6 over-expression, as IKK-2 and IKKß inhibitors inhibited IL-6 expression by 56.5 % and 60.8 %, respectively
O'Connell et al., J Biol Chem 1998 : Recently, we have reported that the tumor necrosis factor and interleukin 1 signaling pathways activate two kinases, IKK1 and IKK2 ... Recently, we have reported that the tumor necrosis factor and interleukin 1 signaling pathways activate two kinases, IKK1 and IKK2