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HP — IL6
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Zauberman et al., Oncogene 1999
(Carcinoma, Hepatocellular...) :
Using a reporter gene construct containing a 190 bp promoter fragment of the acute phase protein haptoglobin we found that p38 is involved in transcriptional
activation of the
haptoglobin promoter by STAT3 but not by
NF-IL6
Guzdek et al., J Physiol Pharmacol 2000
:
In human hepatoma HepG2 cells IL-4 and IL-13 ( but not IL-10 ) inhibited
IL-6 induced synthesis of
haptoglobin
Zauberman et al., J Biol Chem 2001
:
We studied
IL-6 induced secretion of the acute phase protein
haptoglobin by hepatoma cells
Piva et al., J Clin Endocrinol Metab 2001
(Endometriosis) :
Interleukin-6 differentially
stimulates haptoglobin production by peritoneal and endometriotic cells in vitro : a model for endometrial-peritoneal interaction in endometriosis
Smeets et al., FEBS Lett 2002
:
In the liver,
haptoglobin expression is mainly
regulated by
interleukin-6 (IL-6)
Melgar et al., Am J Physiol Gastrointest Liver Physiol 2005
(Acute Disease...) :
The acute colitis was accompanied by elevated plasma levels of
haptoglobin and
increased colonic levels of IL-1alpha/beta,
IL-6 , IL-18, and granulocyte colony stimulating factor
Guetta et al., Atherosclerosis 2007
(Hemorrhage...) :
We found that the
haptoglobin 1 allele protein product-hemoglobin complex
stimulated the secretion of significantly more
Il-6 and Il-10 than the haptoglobin 2 allele protein product-hemoglobin complex
Raynes et al., Clin Exp Immunol 1991
(Carcinoma, Hepatocellular...) :
The HuH-7 cell line is IL-6 responsive since
haptoglobin is
stimulated mainly by
IL-6
Mackiewicz et al., J Immunol 1991
(Carcinoma, Hepatocellular...) :
Haptoglobin was also
induced only by
IL-6 , but TNF-alpha was the only cytokine that inhibited this induction at all concentrations of IL-6
Natsuka et al., FEBS Lett 1991
:
Then, we examined the
effect of the overproduced
NF-IL6 and delNFIL6 on the expression of
haptoglobin , fibrinogen and albumin ... As a result, basal production as well as
induction of
haptoglobin by
IL-6 were augmented by the expression of NF-IL6, whereas delNFIL6 blocked the production of haptoglobin, fibrinogen and albumin
Arambasić et al., IUBMB Life 2010
(Acute-Phase Reaction) :
Upregulation of
haptoglobin (Hp) expression in the rat during the acute phase ( AP ) response is the
result of synergistic effects of
IL-6- , IL-1beta-, and corticosterone activated signaling pathways
Nerstedt et al., Diabetologia 2010
:
AICAR and metformin markedly blunt the
IL-6 stimulated expression of SAA cluster genes as well as of
haptoglobin in a dose dependent manner
Oliviero et al., EMBO J 1989
:
Transcription of the human
haptoglobin (Hp) gene is
induced by
interleukin-6 (IL-6) in the human hepatoma cell line Hep3B ... Our results indicate that the
IL-6 response of the
haptoglobin promoter is dependent on the presence of multiple, partly redundant, cis acting elements
Nakagawa-Tosa et al., J Vet Med Sci 1995
:
To explore possible regulatory factors unique to ruminants, we examined
effects of
interleukin (IL)-6 , IL-1 and tumor necrosis factor (TNF), on
haptoglobin (Hp) synthesis using a primary culture system of bovine hepatocytes
Piquet-Pellorce et al., Exp Cell Res 1994
(Carcinoma, Hepatocellular...) :
Though
IL-6 , LIF, and OSM all
stimulate haptoglobin and fibrinogen production by human HepG2 hepatoma cells, the dose-response curves of these three factors exhibit very different characteristics
Peppard et al., Cell Immunol 1994
:
The
stimulation of
haptoglobin by
IL-6 was abolished in the presence of 5 micrograms/ml actinomycin D and was thus likely pretranslational
Weiergräber et al., Eur J Biochem 1995
:
Haptoglobin mRNA synthesis was
induced by the soluble
IL-6 receptor at concentrations as low as 10 ng/ml. Five monoclonal antibodies were generated
Karlsson et al., Hepatology 1998
(Carcinoma, Hepatocellular...) :
Simultaneous heat shock and
IL-6 stimulation
caused a synergistic enhancement of
haptoglobin expression, with secretion rates increasing up to 30-fold compared with unstimulated control cells