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CPOX — IL6

Text-mined interactions from Literome

Moore et al., J Appl Physiol 2001 : In human cultured airway smooth muscle cells, interleukin (IL)-1 beta increases cyclooxygenase (COX)-2 expression and PGE ( 2 ) release, ultimately resulting in decreased beta-adrenergic responsiveness
Moon et al., Toxicol Appl Pharmacol 2003 : The purpose of this investigation was to test the hypothesis that the inducible cyclooxygenase-2 (COX-2) and its metabolites contribute to VT-induced IL-6 upregulation ... Superinduction of lipopolysaccharide (LPS) mediated IL-6 production by VT in these cells was significantly reduced by the COX inhibitors indomethacin and NS-398, whereas the inhibitors did not affect direct induction of IL-6 by LPS alone
Bukata et al., J Orthop Res 2004 (Osteolysis...) : Interestingly, COX-2 was also required for IL-6 production in these assays, which could be rescued by the addition of exogenous PGE2 ( 10 ( -6 ) M )
Helmersson et al., Free radical research 2005 (Cardiovascular Diseases...) : This study investigated the longitudinal association between serum selenium ( s-Se ) and a golden standard indicator of oxidative stress in vivo ( 8-iso-prostaglandin F2alpha, a major F2-isoprostane ), an indicator of cyclooxygenase (COX) mediated inflammation ( prostaglandin F2alpha ), high sensitive C-reactive protein ( hsCRP ), interleukin-6 (IL-6) and serum amyloid A protein (SAA) in a follow-up study of 27 years
Chen et al., J Immunol 2006 : PGN mediated IL-6 production was inhibited by a nonselective cyclooxygenase (COX) inhibitor ( indomethacin ), a selective COX-2 inhibitor ( NS398 ), a PGE ( 2 ) ( EP2 ) antagonist ( AH6809 ), a PGE ( 4 ) ( EP4 ) antagonist ( AH23848 ), and a protein kinase A (PKA) inhibitor ( KT5720 ), but not by a nonselective NO synthase inhibitor ( N ( G ) -nitro-l-arginine methyl ester )
Herseth et al., Toxicol In Vitro 2009 : Role of IL-1 beta and COX2 in silica induced IL-6 release and loss of pneumocytes in co-cultures ... In this study we investigated the role of IL-1 beta, TNF-alpha and COX2 in silica induced regulation of IL-6 release and pneumocyte loss in various mono- and co-cultures of monocytes, pneumocytes and endothelial cells ... Inhibition of COX2 markedly reduced both IL-1 beta and IL-6 release
Li et al., Glia 2011 : Nonselective and COX2-selective inhibitors blocked TLR3 induction of TNFa and IL-6
Yoon et al., PloS one 2011 (Graves Disease...) : Quercetin significantly attenuated intercellular adhesion molecule-1 ( ICAM-1 ), interleukin (IL) -6, IL-8, and cyclooxygenase (COX) -2 mRNA expression, and inhibited IL-1ß induced increases in ICAM-1, IL-6 , and IL-8 mRNA
Arslan et al., Prostaglandins 1996 : In these cells, COX-2 gene expression was inducible by the cytokines interleukin-1 beta and tumor necrosis factor alpha, but not by interleukin-6
Dean et al., J Biol Chem 1999 : We have previously shown that the pyridinyl imidazole SB 203580, which inhibits it, blocks the interleukin-1 induction of cyclooxygenase-2 (COX-2) and matrix metalloproteinase 1 and 3 mRNAs in fibroblasts