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JUN — RARB
Text-mined interactions from Literome
Soprano et al., J Cell Biochem 2000
:
Murine
RARbeta4 displays
reduced transactivation activity, lower affinity for retinoic acid, and no
anti-AP1 activity ... The results demonstrate that
RARbeta1 , beta2, and beta3 bind RA with a similar K ( d ) value, have a similar EC ( 50 ) value in RA-dependent transactivation assays and
inhibit AP1 activity to a similar level
De-Castro Arce et al., J Biol Chem 2004
:
Because AP-1 activity was not irreversibly disturbed, but could be switched on through activation of the Jun N-terminal kinase pathway, a model for the transient activation of
AP-1 even in the
presence of
RARbeta as repressor is suggested