◀ Back to CCR4

CCL17 — CCR4

Pathways - manually collected, often from reviews:

• KEGG Cytokine-cytokine receptor interaction: CCL17 → CCR4 (protein-protein, activation)
• KEGG Chemokine signaling pathway: CCL1/CCL11/CCL13/CCL14/CCL15/CCL16/CCL17/CCL18/CCL19/CCL2/CCL20/CCL21/CCL22/CCL23/CCL24/CCL25/CCL26/CCL27/CCL28/CCL3/CCL3L1/CCL3L3/CCL4/CCL4L1/CCL4L2/CCL5/CCL7/CCL8/CX3CL1/CXCL1/CXCL10/CXCL11/CXCL12/CXCL13/CXCL14/CXCL16/CXCL2/CXCL3/CXCL5/CXCL6/CXCL9/IL8/PF4/PF4V1/PPBP/XCL1/XCL2 → CCR1/CCR10/CCR2/CCR3/CCR4/CCR5/CCR6/CCR7/CCR8/CCR9/CX3CR1/CXCR1/CXCR2/CXCR3/CXCR4/CXCR5/CXCR6/XCR1 (protein-protein, activation)
  
• WikiPathways Chemokine signaling pathway: CCL19/CCL27/CXCL3/CXCL10/XCL1/CXCL9/CCL21/CCL1/CCL11/CCL7/CCL17/CCL20/CCL22/CCL25/CCL27/CCL3/CCL4/CCL5/CCL15/CCL7/CCL15/CXCL3/CXCL5/CX3CL1/CXCL12/CCL19/CCL26/CXCL13/CXCL11/CCL24/PF4/CCL28/CXCL14/PPBP/CCL21/CXCL16 → CXCR5/CCR6/CXCR2/CXCR3/CXCR4/CCR1/CCR9/CCR1/CCR3/CCR2/CCR4/CCR2/CCR7/CCR8/CCR10/CX3CR1/CXCR2/XCR1/CXCR6 (activation)
  

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Dip Interaction: CCL17 — CCR4 (physical association, experimental interaction detection) Kitaura et al., J Biol Chem 1999*
• IRef Dip Interaction: CCL17 — CCR4 (physical association, biochemical) Imai et al., J Biol Chem 1997*
• IRef Dip Interaction: CCL17 — CCR4 (physical association, experimental interaction detection) Baba et al., J Biol Chem 1997*
• IRef Dip Interaction: CCL17 — CCR4 (physical association, biochemical) Imai et al., J Biol Chem 1998*
• IRef Dip Interaction: CCL17 — CCR4 (physical association, experimental interaction detection) Youn et al., Blood 1999*
• IRef Hprd Interaction: CCL17 — CCR4 (in vivo) Imai et al., J Biol Chem 1997*, Imai et al., J Biol Chem 1998*
• IRef Hprd Interaction: CCL17 — CCR4 (in vitro) Imai et al., J Biol Chem 1997*, Imai et al., J Biol Chem 1998*
• IRef Innatedb Interaction: CCL17 — CCR4 (unknown, -) Imai et al., J Biol Chem 1997*
• IRef Ophid Interaction: CCL17 — CCR4 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• STRING interaction: CCL17 — CCR4 (interaction, mapped from kegg_pathways)
• STRING interaction: CCR4 — CCL17 (interaction, mapped from kegg_pathways)

Text-mined interactions from Literome

Yu et al., J Dermatol Sci 2002 : The CC chemokine thymus- and activation regulated chemokine ( TARC/CCL17 ) acts on CC chemokine receptor 4 (CCR4) , which is known to be selectively expressed in Th2 cells
Mariani et al., Eur J Immunol 2004 : The differential CCR4 desensitization and internalization reported here and the distinct expression patterns of CCL17 and CCL22 observed in vivo suggest that while CCL17 may act first on CCR4 at the endothelial surface to promote vascular recognition, CCL22 could subsequently engage the receptor within the tissue microenvironment to guide cellular localization
Trujillo et al., Am J Pathol 2008 (Pulmonary Fibrosis) : Thus, these results demonstrate that CCL17 dependent activation of CCR4 in macrophages plays a central role in free radical induced pulmonary injury and repair
Traeger et al., Infect Immun 2008 (Peritonitis...) : CASP induced sepsis led to a massive downregulation of CCR4 in lymphoid and nonlymphoid tissues, whereas the expression of CCL17 and CCL22 was independent of the presence of CCR4