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CIDEC — INS

Text-mined interactions from Literome

Ito et al., J Lipid Res 2010 : Insulin decreased CIDEA and increased CIDEC but not CIDEB mRNA expression ... Lipid droplet size of adipocytes was increased when insulin increased the CIDEC mRNA level
Ito et al., J Lipid Res 2011 (Obesity) : Differential regulation of CIDEA and CIDEC expression by insulin via Akt1/2- and JNK2 dependent pathways in human adipocytes ... Previously, we reported that CIDEA and CIDEC are differentially regulated by insulin and contribute separately to insulin induced anti-apoptosis and lipid droplet formation in human adipocytes ... Here, we investigated the signaling molecules involved in insulin regulation of CIDEA and CIDEC expression ... The phosphatidylinositol 3-kinase (PI3K) inhibitors wortmannin and PI-103 blocked both insulin induced downregulation of CIDEA and upregulation of CIDEC ... The Akt inhibitor API-2 and the c-Jun N-terminal kinase (JNK) inhibitor SP600125 selectively inhibited insulin regulation of CIDEA and CIDEC expression, respectively, whereas the MAPK/ERK kinase inhibitor U0126 and the p38 inhibitor SB203580 did not ... These results suggest that insulin regulates CIDEA and CIDEC expression via PI3K, and it regulates expression of each protein via Akt1/2- and JNK2 dependent pathways, respectively, in human adipocytes