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IL2 — PLCG1
Text-mined interactions from Literome
Verí et al., Mol Cell Biol 2001
:
Raft targeted
PLCgamma1 was constitutively tyrosine phosphorylated and
induced constitutive NF-AT dependent transcription and
interleukin-2 secretion in Jurkat cells
Finkelstein et al., J Immunol 2005
:
T cells deficient in the Tec kinases Itk or Itk and Rlk exhibit defective TCR stimulated proliferation,
IL-2 production, and
activation of
phospholipase C-gamma
Chuck et al., J Immunol 2010
(Lymphoproliferative Disorders) :
Analysis of LATY136F T cells indicated that the interaction between LAT and
PLC-gamma1 plays an important role in TCR mediated signaling, proliferation, and
IL-2 production
Nakano et al., Mol Cell Biol 1994
:
Activation of
phospholipase C-gamma 1 through transfected platelet derived growth factor receptor
enhances interleukin 2 production upon antigen stimulation in a T-cell line ... However, the activation mechanism of
PLC gamma 1 and the
role of the phosphatidylinositol pathway for
interleukin 2 (IL-2) production in T lymphocytes remain to be determined
Hubert et al., J Immunol 1996
:
By contrast, CD2
induces PLCgamma-1 tyrosine phosphorylation as efficiently as CD3, with a correlated inositol phosphate production and intracellular calcium increase, and even a higher production of
IL-2
Kennedy et al., J Biol Chem 1998
:
These results indicate that
PLC-gamma1 activation
plays pivotal and pleiotropic roles in the stimulation of
IL-2 gene expression, whereas activation of PI3-K negatively modulates this response in Jurkat T cells