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SKP1 — TYR

Text-mined interactions from Literome

Nakajima et al., Arch Dermatol Res 2012 (Hyperpigmentation) : Real-time RT-PCR and western blotting of Ax-treated HEEs revealed that the SCF stimulated expression of tyrosinase (TYR) , TYR related protein-1 (TYRP1), and Pmel17, as well as microphthalmia associated transcription factor ( MITF ), is significantly suppressed by Ax at the transcriptional and translational levels
Wakabayashi et al., J Dermatol Sci 2013 (Lentigo) : Real-time RT-PCR and Western blotting of these NCM treated HEEs unexpectedly revealed that the EDN1+SCF stimulated steady-state levels of tyrosinase (TYR) , TYR related protein-1, dopachrome tautomerase and PMEL17 as well as microphthalmia associated transcription factor ( MITF ) were significantly attenuated at the transcriptional and translational levels without any cytotoxic effects on keratinocytes and melanocytes in the HEEs ... Pre-treatment of cultured normal human melanocytes with the NCMs interrupted the EDN1+SCF induced stimulation of steady-state levels of MITF at the transcriptional and translational levels and TYR activity without any direct inhibitory effect on the catalytic activity of TYR in vitro
Shin et al., Exp Mol Med 2013 (Melanoma, Experimental) : Glyceollins inhibited melanin synthesis, as well as the expression and activity of tyrosinase induced by SCF , in a dose dependent manner in B16F10 melanoma cells