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EPHB2 — PTEN

Text-mined interactions from Literome

Mosser et al., Biochem Biophys Res Commun 2001 (MAP Kinase Signaling System) : In Cos-7 cells, overexpression of wild-type PTEN had no effect on ERK2 phosphorylation in response to acute insulin stimulation
Huang et al., Arterioscler Thromb Vasc Biol 2002 : PTEN was expressed endogenously in VSMCs, and PTEN overexpression inhibited PDGF induced phosphorylation of p70 ( s6k ), Akt, and glycogen synthase kinase-3-alpha and -beta but not ERK1 or -2
Zhang et al., Chin J Cancer 2002 (Endometrial Neoplasms) : [ Role of suppressor encoprotein PTEN in IGF-1 induced activation of ERK in endometrial carcinoma cells ] ... The objective of this paper was to study extracellular signal regulated kinase ( ERK ) activation in endometrial carcinoma cell line Ishikawa under the stimulation of IGF-1, and to elucidate the role of suppressor encoprotein phosphatase and tensin homologue(PTEN) in activation of ERK ... The activation of ERK2 was inhibited obviously by PTEN at 30 min, 2 h, and 24 h ... The activation of ERK2 was inhibited obviously by PTEN , not by PTEN ( G129E )
Zhang et al., Chin Med J (Engl) 2003 (Endometrial Neoplasms) : The activation of ERK2 was inhibited markedly by PTEN , but not by PTEN ( G129E )
Kanda et al., J Cancer Res Clin Oncol 2009 (Prostatic Neoplasms...) : Stable PTEN expression in PTEN-null UM-UC-3 cells increased serum induced ERK activation and sensitivity to PD98059-treatment, and reduced sensitivity to LY294002 after 6 weeks of exposure
Takashima et al., J Gastroenterol 2009 : Expression of WT-PTEN also caused decreased activation of Akt, p70 ( S6K ), and Erk signaling pathways
Thomas et al., Neuro Oncol 2010 (Brain Neoplasms...) : PTEN augments SPARC suppression of proliferation and inhibits SPARC induced migration by suppressing SHC-RAF-ERK and AKT signaling
Chetram et al., Mol Cancer Res 2011 (Prostatic Neoplasms) : By Western blot analysis, we observed that PTEN inhibited basal AKT phosphorylation but not ERK1/2 phosphorylation in PTEN expressing cells ... Upon CXCR4 stimulation, PTEN inhibited ERK1/2 phosphorylation but not phosphorylation of AKT
Chetram et al., J Recept Signal Transduct Res 2012 (MAP Kinase Signaling System...) : PTEN regulation of ERK1/2 signaling in cancer ... However, the detailed mechanism by which PTEN regulates ERK1/2 is poorly understood ... In this review, we discuss the role of PTEN in regulating ERK1/2 by directly targeting shc/Raf/MEK and PI3K/AKT cascades, and a putative cross-talk between the two
Gupta et al., Mol Biol Cell 2012 (Alzheimer Disease...) : Results suggest that PTEN acting through FAK, the direct protein substrate of PTEN, prevents ERK activation