Natarajan et al., J Immunol 2001
(Second Messenger Systems) :
Whereas B cell Ag receptor (BCR) cross linking alone stimulated increased expression of CD86 , up-regulation of CD80 required dual stimulation with anti-IgM and anti-CD54
Marshall-Clarke et al., Immunology 2003
:
We show that activity of the enzyme phosphatidylinositol 3-kinase is critical for MHC II hyperexpression and induction of CD86 in response to ligation of the BCR or CD38, but not for responses to other stimuli including interleukin-4, lipopolysaccharide and CD40 ligation