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PTEN — SLC22A3

Text-mined interactions from Literome

Leslie et al., Curr Biol 2007 : Overexpression of PTEN strongly inhibits the epithelial-to-mesenchymal transition ( EMT ) of mesoderm cells ingressing through the anterior and middle primitive streak, but it does not affect EMT of cells located in the posterior streak ... Expression either of PTEN lacking the PDZ binding site or of the PTEN C2 domain, or inhibition of PI3K through specific inhibitors, does not inhibit EMT , but results in a loss of both cell polarity and directional migration of mesoderm cells
Han et al., PloS one 2012 (Breast Neoplasms...) : Interestingly, down-regulation of PTEN by siPTEN suppressed the effects of miR-21 antagomir on EMT and CSC phenotype, confirming that PTEN is a target of miR-21 in reversing EMT and CSC phenotype
Bao et al., Cancer Lett 2013 (Carcinoma, Hepatocellular...) : Therefore, miR-21 mediated suppression of both hSulf-1 and PTEN led to activation of AKT/ERK pathways and epithelial-mesenchymal transition (EMT) in HCC cells, and finally enhance the activity of HCC cell proliferation and movement and promote HCC xenograft tumor growth in mouse models