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CA2 — PTGS2
Text-mined interactions from Literome
Choudhary et al., J Bone Miner Res 2003
:
We conclude that [
Ca2+ ] e is a potent transcriptional
inducer of
COX-2 expression and PGE2 production in osteoblasts through an ERK signaling pathway
Slice et al., J Biol Chem 2005
:
Inhibition of
Ca2+ signaling by 2-aminobiphenyl borate
blocked Ang II-dependent
COX-2 expression ... Luciferase promoter assays showed that Ang II-dependent transcriptional activation of the
COX-2 promoter was
dependent on activation of small GTPases and p38 ( MAPK ) and on
Ca2+ signaling via the cAMP-responsive element/activating transcription factor cis acting element
Katagiri et al., J Bone Miner Res 2006
(Bone Resorption...) :
CA II activity was
inhibited by sulfonamide-type
COX-2 selective agents celecoxib and JTE-522 similarly to a CA II inhibitor acetazolamide, but not by a methylsulfone-type COX-2 inhibitor rofecoxib
Pham et al., J Cell Biochem 2006
:
The combined
effect of PKC and
Ca2+ signaling were prolonged
COX-2 and mPGES-1 mRNA and protein expression ... Inhibition of PKC activity, MEK activity, or
Ca2+ signaling
blocked agonist induction of
COX-2 and mPGES-1
Ogata et al., Biochem Biophys Res Commun 2006
(Calcium Signaling) :
Ca2+ stimulates
COX-2 expression through calcium sensing receptor in fibroblasts