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FUT1 — SMAD3

Text-mined interactions from Literome

Schnabl et al., Hepatology 2001 (Drug-Induced Liver Injury...) : In conclusion, ( 1 ) maximal expression of collagen type I in activated HSCs requires Smad3 in vivo and in culture ; ( 2 ) Smad3 is not necessary for HSC activation as assessed by alpha-SMA expression ; ( 3 ) Smad3 is necessary for inhibition of proliferation of HSCs, which might be TGF-beta dependent ; and ( 4 ) Smad3 is required for TGF-beta1 mediated Smad containing DNA binding complex formation in cultured HSCs
Hasegawa et al., Arthritis Rheum 2009 (Disease Models, Animal...) : Pretreatment with HSc025 prevented Smad dependent promoter activation, in a dose dependent manner ; however, HSc025 had no effect on TGFbeta induced phosphorylation of Smad3