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NOTCH1 — SMAD4
Text-mined interactions from Literome
Abe et al., Mech Dev 2005
:
Notch signal activation
restored the ability of C-terminal phosphorylated smad2 to bind to
smad4 , resulting in a delay in the onset of LMC
Fu et al., J Biol Chem 2009
:
This is the first evidence that
Notch activation
affects R-Smad expression and that cooperative induction of histone acetylation at specific promoters underlies the selective synergy between Notch and TGFbeta signaling pathways