◀ Back to PIM1
CDKN1A — PIM1
Pathways - manually collected, often from reviews:
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OpenBEL Selventa BEL large corpus:
CDKN1A
→
PIM1
(decreases, CDKN1A Activity)
Evidence: Fig. 2. Pim-1 is post-transcriptionally regulated by stabilization on the mRNA and protein level and degraded by PP2A.The phosphorylation by Pim-1 results in an inactivation of repressors or activation of transcription factors or regulatory proteins, in the stabilization of proteins, which are involved in signaling pathways and in the inactivation of pro-apoptotic proteins.
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
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IRef Biogrid Interaction:
CDKN1A
—
PIM1
(direct interaction, enzymatic study)
Wang et al., Biochim Biophys Acta 2002*
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IRef Biogrid Interaction:
CDKN1A
—
PIM1
(direct interaction, pull down)
Wang et al., Biochim Biophys Acta 2002*
-
IRef Hprd Interaction:
CDKN1A
—
PIM1
(in vivo)
Wang et al., Biochim Biophys Acta 2002*
-
IRef Hprd Interaction:
CDKN1A
—
PIM1
(in vitro)
Wang et al., Biochim Biophys Acta 2002*
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IRef Ophid Interaction:
CDKN1A
—
PIM1
(aggregation, confirmational text mining)
Wang et al., Biochim Biophys Acta 2002*
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IRef Ophid Interaction:
CDKN1A
—
PIM1
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Wang et al., Biochim Biophys Acta 2002
(Leukemia, Monocytic, Acute) :
During phorbol ester induced differentiation of U937 cells, both Pim-1 and
p21 expression levels
increase with
Pim-1 levels increasing in both the nucleus and cytoplasm while p21 remains primarily cytoplasmic ... Consistent with the results from the phosphoamino acid assay,
Pim-1 phosphorylates transfected p21 only on Thr ( 145 ) in p21-deficient human fibroblasts and this phosphorylation event
results in the cytoplasmic localization of
p21
Zhang et al., Mol Cancer Res 2007
(Lung Neoplasms) :
Pim-1 kinase
dependent phosphorylation of
p21Cip1/WAF1 regulates its stability and cellular localization in H1299 cells
Hogan et al., J Biol Chem 2008
(Lymphoma, Mantle-Cell) :
Additionally,
Pim-1 induces endogenous ARF, p53, Mdm2, and
p21 in primary murine embryo fibroblasts and stimulates senescence associated beta-galactosidase levels, consistent with the induction of senescence