Gene interactions and pathways from curated databases and text-mining

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NFYB — SREBF1

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Nackley et al., Endocrinology 2002 : YY1 inhibited SREBP-1a/nuclear factor Y (NF-Y) enhancement of StAR activation and YY1 decreased SREBP-1a binding to a sterol regulatory element in the presence or absence of NF-Y
Damiano et al., Biochem J 2009 : Our data show that PUFA inhibition of hepatic Cic gene transcription is mediated not only by the nuclear level of SREBP-1c , but also might involve a reduction in Sp1 and NF-Y DNA binding, suggesting differential mechanisms in the Cic gene regulation by different PUFA
Ericsson et al., J Biol Chem 1996 : We now demonstrate that the binding of recombinant SREBP-1 to its cognate site ( SRE-3 ) within the FPP synthase promoter in vitro is enhanced by binding of NF-Y to the upstream inverted CCAAT box ... In contrast, NF-Y does not stimulate the binding of SREBP-1 to SRE-3 when the inverted CCAAT box is either mutated or 4 base pairs ( bp ) are inserted between the inverted CCAAT box and SRE-3 ... These studies suggest that the binding of SREBP-1 to SRE-3 in the FPP synthase promoter, and subsequent stimulation of transcription, is dependent on synergistic binding and a functional interaction between SREBP-1 and NF-Y
Jackson et al., J Lipid Res 1998 : Gel mobility shift assays demonstrated that the synergistic binding of SREBP-1a to SRE-3 was dependent on the binding of recombinant nuclear factor Y (NF-Y) to the DNA, consistent with the in vivo regulation studies