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IL2 — TSC22D3
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Ayroldi et al., Mol Cell Biol 2002
(MAP Kinase Signaling System) :
In fact,
GILZ overexpression
inhibits TCR activated NF-kappaB nuclear translocation,
interleukin-2 production, FasL upregulation, and the consequent activation induced apoptosis
Asselin-Labat et al., Blood 2004
:
We report here that
IL-2 deprivation
leads to expression of
GILZ in T lymphocytes
Asselin-Labat et al., Mol Endocrinol 2005
:
Indeed, we show that GCs failed to induce
GILZ expression in the
presence of
IL-2 , a cytokine known to antagonize GC effects in T cells ... Using a constitutive active mutant of protein kinase B that inactivates FoxO3 or a FoxO3 mutant that can not be inactivated by protein kinase B, we demonstrate that
IL-2 inhibitory
effects on
GILZ expression are mediated through inhibition of FoxO3 transcriptional activity