Gene interactions and pathways from curated databases and text-mining

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ALOX5 — MAPK3

Text-mined interactions from Literome

Werz et al., Blood 2002 : In contrast, stress induced product formation and translocation of 5-LO , as well as activation of p38 MAPK , occurred also after Ca ( ++ ) depletion
Cerioni et al., Biochim Biophys Acta 2008 : Sequential activation of cytosolic phospholipase A2 (cPLA2) and 5-lipoxygenase (5-LO) , critically regulated by extracellular signal regulated kinase 1 and 2 ( ERK1/2 ) -dependent phosphorylation, mediates U937 cell survival to peroxynitrite
Ha et al., Exp Mol Med 2011 : We describe an alternative ROS production pathway that is triggered by CD40 ligation, involves 5-lipoxygenase (5-LO) , and results in activation of p38 MAPK