Sallmyr et al., Blood 2008
(Leukemia, Erythroblastic, Acute) :
Increased ROS levels appear to be produced via STAT5 signaling and activation of RAC1 , an essential component of ROS producing NADPH oxidases
Xu et al., Cell cycle (Georgetown, Tex.) 2010
:
Others have shown that Rac1 is required for integrin mediated STAT5 activation, but molecules upstream of Rac1 remain to be elucidated
Barros et al., Nucleic Acids Res 2012
:
Because STAT5 stimulation in epithelial cells can also be triggered by Rac1 signalling, we asked whether both factors have opposing roles in transcriptional regulation and whether Rac1 signalling may coordinate a transcription factor switch