◀ Back to PLCB1
GNA15 — PLCB1
Pathways - manually collected, often from reviews:
-
KEGG Chagas disease (American trypanosomiasis):
GNA11/GNA14/GNA15/GNAQ
→
PLCB1/PLCB2/PLCB3/PLCB4
(protein-protein, activation)
-
KEGG Amoebiasis:
GNA11/GNA14/GNA15/GNAQ
→
PLCB1/PLCB2/PLCB3/PLCB4
(protein-protein, activation)
-
KEGG Calcium signaling pathway:
GNA11/GNA14/GNA15/GNAQ
→
PLCB1/PLCB2/PLCB3/PLCB4
(protein-protein, activation)
-
NCI Pathway Database IL8- and CXCR1-mediated signaling events:
GNA15/GTP complex (GNA15)
→
PLC beta (PLCB3/PLCB2/PLCB1)
(modification, activates)
Wu et al., Science 1993
Evidence: genetic interaction
-
NCI Pathway Database Endothelins:
None
→
ETB receptor/Endothelin-1/Gq/GTP/PLC beta complex (EDNRB-EDN1-GNA11_GNAQ_GNA15_GNA14-PLCB3_PLCB2_PLCB1)
(modification, collaborate)
Aramori et al., J Biol Chem 1992, Takuwa et al., Am J Physiol 1989, Resink et al., Biochem Biophys Res Commun 1988
Evidence: assay, other species
-
NCI Pathway Database Endothelins:
ETB receptor/Endothelin-1/Gq/GTP/PLC beta complex (EDNRB-EDN1-GNA11_GNAQ_GNA15_GNA14-PLCB3_PLCB2_PLCB1)
(modification, activates)
Aramori et al., J Biol Chem 1992, Takuwa et al., Am J Physiol 1989, Resink et al., Biochem Biophys Res Commun 1988
Evidence: assay, other species
-
NCI Pathway Database Endothelins:
ETB receptor/Endothelin-1/Gq/GTP/PLC beta complex (EDNRB-EDN1-GNA11_GNAQ_GNA15_GNA14-PLCB3_PLCB2_PLCB1)
→
None
(modification, activates)
Aramori et al., J Biol Chem 1992, Takuwa et al., Am J Physiol 1989, Resink et al., Biochem Biophys Res Commun 1988
Evidence: assay, other species
-
NCI Pathway Database Plasma membrane estrogen receptor signaling:
Gq family/GTP complex (GNA11_GNAQ_GNA15_GNA14)
→
PLC beta (PLCB3/PLCB2/PLCB1)
(modification, activates)
Le Mellay et al., J Biol Chem 1997
Evidence: mutant phenotype, assay, other species
-
NCI Pathway Database Endothelins:
ETA receptor/Endothelin-1/Gq/GTP/PLC beta complex (EDNRA-EDN1-GNA11_GNAQ_GNA15_GNA14-PLCB3_PLCB2_PLCB1)
→
PLC beta (PLCB3/PLCB2/PLCB1)
(modification, collaborate)
Aramori et al., J Biol Chem 1992
-
NCI Pathway Database Endothelins:
ETA receptor/Endothelin-1/Gq/GTP/PLC beta complex (EDNRA-EDN1-GNA11_GNAQ_GNA15_GNA14-PLCB3_PLCB2_PLCB1)
→
ETA receptor/Endothelin-1/Gq/GTP complex (EDNRA-EDN1-GNA11_GNAQ_GNA15_GNA14)
(modification, collaborate)
Aramori et al., J Biol Chem 1992
-
NCI Pathway Database Endothelins:
PLC beta (PLCB3/PLCB2/PLCB1)
→
ETA receptor/Endothelin-1/Gq/GTP complex (EDNRA-EDN1-GNA11_GNAQ_GNA15_GNA14)
(modification, collaborate)
Aramori et al., J Biol Chem 1992
-
NCI Pathway Database PAR1-mediated thrombin signaling events:
Gq family/GTP complex (GNA11_GNAQ_GNA15_GNA14)
→
PLC beta (PLCB3/PLCB2/PLCB1)
(modification, activates)
Hung et al., J Biol Chem 1992
Evidence: genetic interaction, other species
-
NCI Pathway Database Endothelins:
None
→
ETA receptor/Endothelin-1/Gq/GTP/PLC beta complex (EDNRA-EDN1-GNA11_GNAQ_GNA15_GNA14-PLCB3_PLCB2_PLCB1)
(modification, collaborate)
Aramori et al., J Biol Chem 1992, Takuwa et al., Am J Physiol 1989, Resink et al., Biochem Biophys Res Commun 1988
Evidence: assay, other species
-
NCI Pathway Database Endothelins:
ETA receptor/Endothelin-1/Gq/GTP/PLC beta complex (EDNRA-EDN1-GNA11_GNAQ_GNA15_GNA14-PLCB3_PLCB2_PLCB1)
→
None
(modification, activates)
Aramori et al., J Biol Chem 1992, Takuwa et al., Am J Physiol 1989, Resink et al., Biochem Biophys Res Commun 1988
Evidence: assay, other species
-
NCI Pathway Database Endothelins:
ETB receptor/Endothelin-1/Gq/GTP/PLC beta complex (EDNRB-EDN1-GNA11_GNAQ_GNA15_GNA14-PLCB3_PLCB2_PLCB1)
→
p38 alpha (MAPK14)
(modification, activates)
Aquilla et al., J Biol Chem 1996
Evidence: mutant phenotype, other species
-
NCI Pathway Database IL8- and CXCR2-mediated signaling events:
GNA15/GTP complex (GNA15)
→
PLC beta (PLCB3/PLCB2/PLCB1)
(modification, activates)
Wu et al., Science 1993
Evidence: genetic interaction
-
NCI Pathway Database Endothelins:
ETB receptor/Endothelin-1/Gq/GTP/PLC beta complex (EDNRB-EDN1-GNA11_GNAQ_GNA15_GNA14-PLCB3_PLCB2_PLCB1)
→
PLC beta (PLCB3/PLCB2/PLCB1)
(modification, collaborate)
Aramori et al., J Biol Chem 1992
-
NCI Pathway Database Endothelins:
ETB receptor/Endothelin-1/Gq/GTP/PLC beta complex (EDNRB-EDN1-GNA11_GNAQ_GNA15_GNA14-PLCB3_PLCB2_PLCB1)
→
ETB receptor/Endothelin-1/Gq/GTP complex (EDNRB-EDN1-GNA11_GNAQ_GNA15_GNA14)
(modification, collaborate)
Aramori et al., J Biol Chem 1992
-
NCI Pathway Database Endothelins:
PLC beta (PLCB3/PLCB2/PLCB1)
→
ETB receptor/Endothelin-1/Gq/GTP complex (EDNRB-EDN1-GNA11_GNAQ_GNA15_GNA14)
(modification, collaborate)
Aramori et al., J Biol Chem 1992
-
Reactome Reaction:
GNA15
→
PLCB1
(reaction)
Singer et al., Nat Struct Biol 2002, Hubbard et al., Cell Signal 2006
-
Reactome Reaction:
GNA15
→
PLCB1
(indirect_complex)
Singer et al., Nat Struct Biol 2002, Hubbard et al., Cell Signal 2006
-
WikiPathways Endothelin Pathways:
GNA15
→
PLCB1
(mim-stimulation)
-
WikiPathways Endothelin Pathways:
GNA15
→
PLCB1
(mim-stimulation)
Text-mined interactions from Literome
Yu et al., Journal of molecular signaling 2008
:
Galpha16 can
activate phospholipase Cbeta ( PLCbeta ) directly like Galphaq
Liu et al., Cell Signal 2010
:
In contrast, these manipulations had no inhibitory effect on
Galpha16QL induced activation of
phospholipase Cbeta
Qian et al., J Biol Chem 1994
:
Expression of the GTPase-deficient G alpha 16 polypeptide
G alpha 16Q212L , a member of the Gq family of heterotrimeric G proteins, constitutively
activated phospholipase C beta activity in Swiss 3T3 cells