Gene interactions and pathways from curated databases and text-mining

◀ Back to NFKB1

FOXP3 — NFKB1

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Grant et al., PLoS Pathog 2006 : Overexpression of Foxp3 in HEK 293T and purified CD4+ T cells resulted in a dose dependent and time dependent decrease in basal levels of nuclear factor-kappaB (NF-kappaB) activation ... These results suggest an expanded role for Foxp3 in regulating NF-kappaB- and CREB dependent cellular and viral gene expression
Holmes et al., J Biol Chem 2007 : Although NFkappaB nuclear translocation is not altered, FoxP3 enhances NFkappaB-p65 binding to HIV-1 LTR
Krejsgaard et al., Leukemia 2008 (Sezary Syndrome...) : In contrast to wt FOXP3, the low molecular splice forms of FOXP3 have no inhibitory effect on nuclear factor-kappaB (NF-kappaB) activity in reporter assays which is in keeping with a constitutive NF-kappaB activity in the malignant T cells
Long et al., Immunity 2009 : NF-kappaB directly promoted the transcription of Foxp3 , and upon T cell receptor ( TCR ) stimulation, c-Rel, a NF-kappaB family member, bound to Foxp3 enhancer region, which is specifically demethylated in natural Treg cells