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INS — UCP1

Text-mined interactions from Literome

Klein et al., Mol Endocrinol 2000 : Thus, insulin inhibits beta3-adrenergic stimulation of UCP-1 , and both MAP kinase and PI 3-kinase are negative regulatory elements in the beta3-adrenergic control of UCP-1 expression
Pedersen et al., Biochem Biophys Res Commun 2001 : To study the regulation of the mitochondrial uncoupling protein 2 and 3 ( UCP2 and UCP3 ), we studied the effect of insulin and muscle contraction on UCP mRNA expression in rat skeletal muscle in vitro ... In conclusion, UCP2 and UCP3 mRNA expression in skeletal muscle are stimulated rapidly by insulin and contraction in vitro, thus the stimulation is direct and not caused by changes in other hormones or metabolites
Imoto et al., Diabetes 2006 (Carcinoma, Hepatocellular...) : TNF-alpha significantly activated ASK1, increased serine phosphorylation of insulin receptor substrate (IRS)-1 , and decreased insulin stimulated tyrosine phosphorylation of IRS-1 and serine phosphorylation of Akt, and all of these effects were inhibited by overexpression of either UCP-1 or MnSOD
Jung et al., Diabetes Res Clin Pract 2007 (Diabetes Mellitus, Type 2) : Mean 24-h UCP levels increased significantly from a baseline to at 36 months in the insulin sensitizers (IS) only group, in the IS plus sulfonylurea combination group and in IS plus insulin combination group ( p < 0.001 ), whereas in the sulfonylurea only group, we could not find statistically significant changes ( p=0.152 )
Kato et al., Diabetes 2008 : Uncoupling protein-2 (UCP-2) also plays a crucial role in the palmitate inhibition of insulin secretion, as confirmed by knockdown experiments, but SREBP-1c contribution to UCP-2 regulation was partial
Chen et al., Brain Res 2008 (Body Weight) : White fat ( WAT ) masses were reduced by both SE and PF. Plasma leptin and insulin were reduced in SE mice ; insulin was further reduced by PF. Brown fat UCP1 and 3 mRNA were increased in SE animals relative to PF animals, possibly promoting thermogenesis
Yonezawa et al., Biochem Biophys Res Commun 2009 : These results suggest that CIDE-A and UCP1 are regulated by insulin and/or fatty acids in mammary epithelial cells and lactating mammary glands, and thereby play an important role in lipid and energy metabolism
Yonezawa et al., Biochem Biophys Res Commun 2009 : These results suggest that UCP4 and BMCP1 are regulated by insulin and/or fatty acids in mammary epithelial cells and lactating mammary glands, and thereby may play an important role in lipid and energy metabolism
Fridell et al., Aging 2009 : To understand the role of mitochondrial uncoupling protein (UCP) in regulating insulin signaling and glucose homeostasis, we created transgenicDrosophila lines with targeted UCP expression in insulin producing cells (IPCs)
Wu et al., Graefes Arch Clin Exp Ophthalmol 2011 (Diabetic Retinopathy) : The purpose of the present study was to investigate the effect of insulin on the mitochondrial membrane potential ( ??m ), reactive oxygen species ( ROS ) production, UCP-2 and VEGF expression in bovine retinal microvascular endothelial cells ( BRECs ) in the presence of normal or high glucose and the related mechanisms
Gao et al., J Bioenerg Biomembr 2011 (Insulin Resistance...) : UCP4 overexpression significantly improved insulin sensitivity, increased tyrosine phosphorylation of IRS-1 in the presence of insulin , and significantly reduced intracellular triglyceride ( TG )
Strack et al., Am J Physiol 1995 : Although corticosterone inhibited and insulin stimulated UCP , these effects were only evident in diabetics and with normoglycemia, respectively
Burcelin et al., Biochem J 1993 (Diabetes Mellitus, Experimental) : This study shows that insulin plays an important role in the regulation of UCP and GLUT4 mRNA and protein concentrations in BAT
Millet et al., J Clin Invest 1997 (Obesity) : To study the effect of insulin on UCP gene expression, six lean and five obese subjects underwent a 3-h euglycemic hyperinsulinemic clamp
Teruel et al., J Cell Physiol 1998 : Inhibition of PI 3-kinase and RAS blocks IGF-I and insulin induced uncoupling protein 1 gene expression in brown adipocytes ... Transient transfection of dominant negative form of phosphatidylinositol (PI) 3-kinase completely blocked the transactivation of the fusion gene UCP1-CAT induced by either IGF-I or insulin , although inhibition of p70S6kinase with rapamycin does not preclude transactivation of the UCP1 promoter by insulin ... Furthermore, transient transfection of dominant negative form of p21-ras or treatment of cells with a mitogen activated protein kinase kinase ( MEK-1 ) inhibitor ( PD098059 ) completely abolished insulin induced UCP1-CAT transactivation