Gene interactions and pathways from curated databases and text-mining

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ADIPOR1 — INS

Text-mined interactions from Literome

Tsuchida et al., J Biol Chem 2004 (Insulin Resistance) : Insulin deficiency induced by streptozotocin increased and insulin replenishment reduced the expression of AdipoR1/R2 in vivo
Cui et al., Cardiovasc Res 2012 (MAP Kinase Signaling System) : Akt and extracellular signal regulated kinase 1/2 ( ERK1/2 ) phosphorylation was increased in insulin treated hearts and in NRVMs. P13K inhibitor LY294002 and Akt1/2 kinase inhibitor but not the ERK1/2 kinase ( MEK ) inhibitors PD98059 and U0126 blocked the insulin induced reduction in AdipoR1 expression and AMPK phosphorylation ... Insulin inhibits myocardial AdipoR1 expression via PI3K/Akt and FoxO1 pathways, and FoxO1 mediates AdipoR1 transcription by binding to its promoter directly
Sattar et al., Cell Biol Int 2012 : The fact that insulin differentially regulates the expression of AdipoR1 and AdipoR2 in muscle and fat cells suggests this is also dependent on the availability of the endogenous ligand, such as Adp for AdipoR1 and AdipoR2 in fat cells
Kwak et al., PloS one 2013 : Drosophila adiponectin receptor in insulin producing cells regulates glucose and lipid metabolism by controlling insulin secretion ... These results indicate that adiponectin receptor in insulin producing cells regulates insulin secretion and controls glucose and lipid metabolism in Drosophila melanogaster