◀ Back to IL4

CCL13 — IL4

Text-mined interactions from Literome

Stellato et al., J Immunol 1999 : IL-4 and IFN-gamma had selective effects on chemokine expression ; IL-4 selectively up-regulated the expression of eotaxin and MCP-4 and potentiated TNF-alpha induced eotaxin, while IFN-gamma markedly potentiated only the TNF-alpha induced expression of RANTES
Benarafa et al., Vet Immunol Immunopathol 2000 : We also report the early induction ( 2h ) of equine eotaxin and MCP-4 , and the up-regulation of MCP-1 by interleukin-4 in dermal fibroblasts, suggesting these chemokines might be involved in equine skin allergic diseases
Nakamura et al., Am J Physiol Lung Cell Mol Physiol 2001 : IL-4 differentially regulates eotaxin and MCP-4 in lung epithelium and circulating mononuclear cells ... To investigate the mechanisms of eosinophil recruitment in allergic airway inflammation, we examined the effects of interleukin (IL)-4 , a Th2-type cytokine, on eotaxin and monocyte chemoattractant protein-4 ( MCP-4 ) expression in human peripheral blood mononuclear cells ( PBMCs ; n = 10 ), in human lower airway mononuclear cells ( n = 5 ), in the human lung epithelial cell lines A549 and BEAS-2B, and in human cultured airway epithelial cells ... IL-4 inhibited eotaxin and MCP-4 mRNA expression induced by IL-1 beta and tumor necrosis factor-alpha in PBMCs but did not significantly inhibit expression in epithelial cells ... IL-1 beta induced eotaxin and MCP-4 protein production was also inhibited by IL-4 in PBMCs, whereas IL-4 enhanced eotaxin protein production in A549 cells ... The divergent effects of IL-4 on eotaxin and MCP-4 expression between PBMCs and epithelial cells may create chemokine concentration gradients between the subepithelial layer and the capillary spaces that may promote the recruitment of eosinophils to the airway in Th2-type responses
Meyer-Hoffert et al., Int Arch Allergy Immunol 2003 : IL-4 and to a lesser extent IL-13 and IFN-gamma stimulated the production of MCP-3 and -4 , eotaxin and eotaxin-2 immunoreactivities
Odaka et al., Int Arch Allergy Immunol 2007 : The Th2 cytokine IL-4 preferentially stimulated the expression of the CC chemokine receptor (CCR) 3-ligand chemokines eotaxin, eotaxin-3, and MCP-4